home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Receptor For New World Haemorrhagic Fever Viruses Found

  February, 7 2007 9:20
your information resource in human molecular genetics
Researchers have identified the receptor that gives New World haemorrhagic fever arenaviruses their entry point into mammalian cells, a discovery that may aid the development of new therapies.

In a paper published online by Nature, Hyeryun Choe and colleagues demonstrate that transferrin receptor 1 (TfR1) is the cellular receptor for four different New World arenaviruses - the Junin, Machupo, Guanarito and Sabia viruses. Treating cultured cells with an antibody against this receptor blocks viral entry and replication.

The transferrin receptor is better known for its role in iron transport - the iron-rich transferrin protein binds and iron becomes transported into the cell. Iron depletion of culture medium enhanced, and iron supplementation decreased, the efficiency of infection by Junin and Machupo viruses. So the study raises the possibility that iron deficiency may be a risk factor for these diseases.


Hyeryun Choe (Harvard Medical School, Boston, MA, USA)
E-mail: hyeryun.choe@childrens.harvard.edu

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.