home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Annotating The Human Genome

 
  February, 7 2007 9:27
your information resource in human molecular genetics
 
     
An important step in the effort to compile a complete catalogue of functional elements in the human genome is to be published in Nature Genetics. A specific chemical signature of DNA sequences that promote the expression of nearby genes has been identified, and researchers should now be able to more accurately predict the location and function of these sequences.

Analysis of the complete sequence of the human genome has identified approximately 25,000 genes, but genes comprise only a small fraction of the genome. At least some of the remainder of the genome consists of sequences called promoters and enhancers that determine when, where, and to what extent each of these genes will be expressed. While promoters are typically found immediately adjacent to genes, enhancers can be located much further away, making it difficult to identify them.

Bing Ren and colleagues examined 1% of the human genome and catalogued a number of different chemical modifications that are made to histones, which are proteins that bind to and package DNA, and are known to be involved in gene regulation. They found that the histones bound to known promoters are marked by chemical modifications that are distinct from those found on histones bound to enhancers. This information enabled the authors to accurately predict the location and function of promoters and enhancers that were independently identified, as well as identify a previously undiscovered enhancer.

Author contact:

Bing Ren (Ludwig Institute for Cancer Research, La Jolla, CA, USA)
E-mail: biren@ucsd.edu

Abstract available online.

(C) Nature Genetics press release


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.