home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

New Role For Gut-Lining Cells?

  March, 8 2007 8:02
your information resource in human molecular genetics
Intestinal epithelial cells, once thought simply to act as a barrier to pathogenic microorganisms, may have a key role in shaping the function of immune cells, a paper published online in Nature suggests.

Mice with an I-kappa-B kinase-beta gene deletion in gut epithelial cells can not fend off infection with the gut parasite Trichuris. They do not develop the appropriate immune response, overproduce a range of inflammatory cytokine proteins and develop severe intestinal inflammation, David Artis and colleagues report.

The findings may have broad implications for understanding the physiological basis of immunity and inflammation in many different diseases of the intestinal tract, including colon cancer and inflammatory bowel disease.

Author contact:

David Artis (University of Pennsylvania, Philadelphia, PA, USA)
E-mail: dartis@vet.upenn.edu

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.