home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Antidepressant Takes The Gloom Off Spinal Injury

  May, 25 2004 6:40
your information resource in human molecular genetics
The antidepressant rolipram help rats recover from spinal cord injury, Damien Pearse and his colleagues report in the June issue of Nature Medicine.

Rolipram acts by preventing the destruction of the intracellular messenger cAMP, a small molecule that affects the growth of nerve fibers. Pearse and colleagues treated spinal cord-injured rats with rolipram in combination with a cAMP analog and grafts of Schwann cells, the cells that produce the insulating sheath around nerve fibers. They found that this treatment significantly improved movement, and promoted the survival and growth of the fibers beyond the lesion site.

The profound effect of this three-pronged strategy might have important implications for therapeutic intervention to improve outcome after human spinal cord injury.

Author contact:

Damien D Pearse (University of Miami School of Medicine, FL, USA)
Tel: +1 305 243 4596, E-mail: dpearse@miamiproject.med.miami.edu

Also published online.

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.