home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Stealing Hepatitis C's Raft

  October, 19 2005 10:17
your information resource in human molecular genetics
Scientists have found a new drug candidate that can be used to stop the liver-damaging Hepatitis C virus (HCV) from multiplying. The research reported in the November issue of Nature Chemical Biology showed that the molecule keeps the virus from hijacking the lipid-making machinery in its host cell, making it harder for the virus to replicate.

RNA-viruses like HIV and HCV are prone to drug resistance. This may be because the drugs target proteins that the virus itself is making. To look for new drug targets and drugs, Hiroshi Sakamoto and colleagues searched a large number of naturally-occurring compounds for their ability to block the replication of the virus. They found one compound, NA255 from a plant fungus that works by blocking the host cell's ability to make certain lipids called sphingolipids. This decreases the availability of specialized lipid structures called rafts that the virus uses as a platform to replicate itself.

Besides increasing our basic knowledge of how HCV replicates itself within host cells, NA255 brings a new strategy to the anti-HCV arsenal by targeting the host cell's machinery.

Author contact:

Hiroshi Sakamoto (Chugai Pharmaceutical Co. Ltd., Kanagawa, Japan)
E-mail: sakamotohrs@chugai-pharm.co.jp

Abstract available online.

(C) Nature Chemical Biology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.