home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Development Of Immune Cells Associated With Allergy And Asthma

 
  October, 19 2005 10:22
your information resource in human molecular genetics
 
     
Arthritis and allergy are 'two sides of the same coin' as immune responses. Both are caused by overproduction of otherwise important immune molecules. Two papers in the November issue of Nature Immunology describe how one type of immune cell associated with allergic inflammation and autoimmunity ultimately causes disease. This new work clarifies how such cells develop, which may help bring treatment for inflammatory diseases such as asthma and allergy.

CD4 lymphocytes (or 'T helper' cells) are immune 'helper' cells that were formerly thought to function in one of two ways during immune responses. Now, work from the laboratories of Casey Weaver and Chen Dong describe how a novel third type of T helper cell develops.

Molecules such as antiviral interferon-gamma (IFN-g) and allergy-associated interleukin 4 (IL-4) are well known to be produced by distinct 'lineages' of T helper cells, whereas distinct molecules have been linked to some T helper cells found in people with autoimmunity. Both Weaver and Dong demonstrate that CD4 T cells can be become producers of interleukin 17 (IL-17), a powerful chemical that stimulates inflammation and has been linked to autoimmunity and allergy. IL-17 is triggered by a unique set of signals that defines this new 'lineage' of CD4 T cells.

This new information may allow treatments for people before they develop symptoms of allergy and autoimmunity instead of only after symptoms occur, which is the basis of the present, less effective treatment.

Author contact:

Casey Weaver (University of Alabama at Birmingham, AL, USA)
E-mail: weaver@path.uab.edu

Chen Dong (University of Texas MD Anderson Cancer Center, Houston, TX, USA)
E-mail: cdong@mdanderson.org

Additional contact for comments on paper:

Thomas A. Wynn (National Institutes of Health, Bethesda, MD, USA)
E-mail: twynn@niaid.nih.gov

Abstracts available online: Paper 1, and Paper 2.

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.