Children With IH And BWS Have Different Constitutional Epigenotypes Associated With Wilms Tumor
Emily L. Niemitz (1), Andrew P. Feinberg (2,3,4), Sheri A. Brandenburg (2), Paul E. Grundy (5,6) and Michael R. DeBaun (7)
(1) Predoctoral Program in Human Genetics and Departments of (2) Medicine, (3) Molecular Biology and Genetics, and (4) Oncology, Johns Hopkins University School of Medicine, Baltimore; Departments of (5) Pediatrics and (6) Oncology, University of Alberta, Edmonton; and (7) Division of Genetics, Department of Pediatrics, Washington University School of Medicine, St. Louis
The frequency of hypermethylation of H19 in children with Idiopathic hemihypertrophy (IH), a congenital overgrowth syndrome associated with an increased risk of embryonal cancers in childhood, and Wilms tumor, 20% (3/15), was significantly lower than the frequency in children with Beckwith-Wiedemann syndrome (BWS), which increases risk for embryonal cancers, and Wilms tumor, 79% (11/14; P = .0028).
These results indicate that children with IH and Wilms tumor have different constitutional epigenotypes from those of children with BWS and Wilms tumor.
Abstract available online.
(C) American Journal of Human Genetics.
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