home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Creation of Targeted Nanoparticles

  May, 10 2006 4:40
your information resource in human molecular genetics
Multifunctional Polymeric Nanoparticles from Diverse Bioactive Agents

Bertin, P.A., Gibbs, J.M., Shen, C.K.F., Thaxton, C.S., Russin, W.A., Mirkin, C.A., Nguyen, S.T. J. Amer. Chem. Soc.,128, 4168-4169 (April 5, 2006).

Scientists at Northwestern University have used a ring-opening metathesis polymerization method to create nanoparticles with a core, which may be used to carry drugs, and a shell surface that permits attachment of single-stranded DNA or tumor-targeting antibodies. The spherical structures were confirmed with transmission electron microscopy as having diameters less than 200 nm. Tosyl groups on the shell surface were used to attach single-stranded oligonucleotides via 5’-terminal amines and antibodies via amines on such amino acids as lysine. Transmission electron microscopy confirmed the attachment of the biologically active moieties. Moreover, when the nanoparticles were conjugated with both anti-HER-2 IgY and Bcl-2 antisense oligodeoxynucleotides, human breast carcinoma cells that overexpress the HER-2 protein internalized the nanoparticles. Exposure of the cells to Bcl-2 alone or to nanoparticles lacking the HER-2 antibodies showed no uptake. Hence, the HER-2 antibodies facilitate the entry of the nanoparticles into the cell.

The authors previously have shown that chemotherapeutic agents can be sequestered in their nanoparticles’ cores. Merging that approach with the one used in the present study should yield a wide range of anticancer therapies, delivered with specificity and with the potential for obtaining synergistic effects of different drug combinations.

Message posted by: Keith Markey

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.