home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Common Genetic Variant Associated With Prostate Cancer

 
  May, 10 2006 13:11
your information resource in human molecular genetics
 
     
A common genetic marker that is found more frequently in men with prostate cancer than those without is reported in a study to be published in the June 2006 issue of Nature Genetics. This the first identification of a major genetic risk factor for prostate cancer in the general population.

Kari Stefansson and colleagues show that a particular marker on chromosome 8 is significantly more frequent in men with prostate cancer in populations studied in Iceland, Sweden, and the United States, including both European and African Americans. About 8% of prostate cancers in Europeans might be attributed to this variant. The genetic marker is significantly associated with high-grade prostate cancer in the four populations studied, and not with the benign precursor to prostate cancer, suggesting that it specifically increases the risk of malignant prostate tumors. The risk variant has not yet been definitively linked to a particular gene, although nearby regions on chromosome 8 harbor several candidates.

The incidence of prostate cancer is increasing and, after skin cancer, is now the most common form of cancer diagnosed in men. African Americans have a particularly high incidence, and are more likely to die from the disease than European Americans. The fact that the identified risk variant is four times more frequent in African Americans than European Americans suggests that it might explain at least a fraction of the elevated risk borne by Americans of African ancestry.

Author contact:

Kari Stefansson (deCODE Genetics, Reykjavik, Iceland)
E-mail: kstefans@decode.is

Abstract available online.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.