- Anticancer Activity Of An Adenoviral Vector Expressing Short Hairpin RNA Against BK Virus T-ag
Study indicates that siRNAs delivery via a viral vector have a potential usefulness as in vivo anticancer tool against viral and cellular oncogenes.
- Mapping Of Angiogenic Markers For Targeting Of Vectors To Tumor Vascular Endothelial Cells
Study shows that a single administration of the AdfVII/IgG1Fc vector destroys the peripheral but not the central vasculature of a tumor spheroid.
- Gene Therapy Targeting To Tumor Endothelium
In this review the authors assess the challenges faced and the vectors that may be suitable for gene delivery to exploit candidate targets.
- Methods For The Selection Of Tagging SNPs: A Comparison Of Tagging Efficiency And Performance
This work demonstrates that when tagging single nucleotide polymorphisms (tSNPs)-based association studies are undertaken, the choice of method for selecting tSNPs requires careful consideration.
- Replication Of Reported Linkages For Dyslexia And Spelling And Suggestive Evidence For Novel Regions On Chromosomes 4 And 17
Sceintists report the first genome-wide linkage analysis for reading and spelling in a sample of 403 families of twins, aged between 12 and 25 years taken from the normal population and unselected for reading ability.
Positron emission tomography has demonstrated that sophisticated imaging techniques have a role in diagnosing complex problems like malignant peripheral nerve sheath tumours.
- Association Of PDCD1 Polymorphisms With Childhood-Onset Systemic Lupus Erythematosus
The aim of this study was to investigate the association of the PDCD1 gene polymorphisms and haplotypes with susceptibility to childhood-onset systemic lupus erythematosu in a Mexican population.
- Partial Duplications Of The MSH2 And MLH1 Genes In Hereditary Nonpolyposis Colorectal Cancer
The contribution of genomic duplications of MSH2 and MLH1 genes to hereditary nonpolyposis colorectal cancer.
- Multiple Mutations Responsible For Frequent Genetic Diseases In Isolated Populations
A selective advantage may explain most of the observations of more than one mutation in either one or several genes causing high frequency of an autosomal recessive disease.
- Genetic Screening For Autosomal Recessive Nonsyndromic Mental Retardation In An Isolated Population In Israel
First example of the establishment of a large-scale genetic screening program for autosomal recessive Nonsyndromic Mental Retardation.
- Population Differences In Gene Expression
Study reveals a significant ethnic variation in gene expression.
- Genetic Risk Factor For Stroke Found
Individuals with a particular variant of the gene PRKCH have a 40% increased risk of cerebral infarction, the most common type of stroke.
- A New Source Of Stem Cells
Amniotic fluid contains stem cells that can be coaxed towards becoming various cell types that might be useful in regenerative medicine.
- Enzyme Double Act Evades Drug Therapy
New study may aid the design of more effective cancer therapies.
- Inhalant Abuse: 'Sniffing' Toluene For A High
Toluene, a commonly abused toxic compound, is shown to stimulate dopamine release in specific regions of the rat brain known as drug reward pathways.
- African Chromosomes In Indigenous British
A globally rare Y chromosome type described previously in only a few West African individuals has been found in a British male.
- Fetal Alcohol Syndrome: Are Cholesterol Supplements The Answer?
Cholesterol supplementation prevents fetal alcohol spectrum defects (FASD) in alcohol-exposed zebrafish embryos.
- Scientists Find A Tunnel That Transfers Lipids
Scientists have determined the structure of CETP, the protein that transfers lipids in the blood from 'good' to 'bad' cholesterol.
- For Goodness Sake
The detection of 'agency', the presence of an active participant in a situation, involves a brain region that is more active in altruistic people.
- Getting Things Into Cells With The Aid Of Small Molecules
Small molecules can be linked to much larger cargoes and deliver them into a variety of cell types.
- Maintaining Immune Regulation
Constant expression of a single protein, Foxp3, is essential to maintain the identity and character of regulatory T (Treg) cells.
- Sizing Up Stem Cells
A gene called latexin has a significant effect on the blood stem cell population in young mice.
- Genetic Risk Factor For Alzheimer Dsease
Individuals with particular variants of the gene SORL1 have a modestly elevated risk of late-onset Alzheimer disease.
- Cancer Cleared By p53 Restoration
Certain types of cancer can be pushed into regression by reactivating the tumour suppressor gene p53.
- Non-Coding RNA Interferes With Transcription
A non-coding RNA represses expression of a cell-cycle-regulated gene by directly interfering with the binding of transcription factors.
- Toward A Genetic Test For Parkinson's Disease
A microarray screening of venous blood RNA identified a set of eight unaffiliated genes that, combined, had predictive power for Parkinson’s disease and another gene that may shed light on disease progression.
- The right balance drives the field of PPAR agonist R&D
A strongly growing market of now more than US$ 6 bln in 2006 for only tow PPAR gamma agonists founds the basis for a heavily researched field of next generation mono, dual or triple PPAR agonists with fine-tuned subtype combinations