home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Beefing Up Resistance To Mad Cow Disease

  January, 4 2007 0:25
your information resource in human molecular genetics
A team of American and Japanese scientists has created cows that lack the protein responsible for mad cow disease according to a report in the January 2007 issue of Nature Biotechnology. A thorough clinical examination of the animals up to the age of 20 months indicates that they are healthy, and laboratory tests of their brain tissue suggests that they are likely to be resistant to mad cow disease, which can be transmitted to humans through consumption of affected beef.

Mad cow disease (or bovine spongiform encephalopathy) is caused by a misfolded form of a particular protein known as a 'prion' protein. Kuroiwa and colleagues genetically engineered cows that are identical to ordinary cows except that they lack the prion protein. Because scientists don't understand the function of this protein in its correctly folded form, it was unclear whether prion-free cows would be healthy. The authors' comprehensive health assessment put this concern to rest, at least for young animals.

Studies to determine whether prion-free cows are resistant to mad cow disease take many years and are currently underway. However, preliminary laboratory tests showed that the animals' brain tissue blocks the spread of misfolded prion protein, unlike the brain tissue of ordinary cows.

Author contacts:

Yoshimi Kuroiwa (Kirin Brewery Co, Tokyo, Japan and Gemini Science Inc, La Jolla, CA, USA)
E-mail: ykuroiwa@hematech.com

James Robl (Hematech, Inc, Sioux Falls, SD, USA)
E-mail: jrobl@hematech.com

Juergen Richt (National Animal Disease Center, USDA, Ames, IA, USA)
E-mail: jricht@nadc.ars.usda.gov

Abstract available online.

(C) Nature Biotechnology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.