home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Cancer Cleared By p53 Restoration

  January, 25 2007 10:51
your information resource in human molecular genetics
Certain types of cancer can be pushed into regression by reactivating the tumour suppressor gene p53, suggest two papers published online by Nature. Although both studies used genetic tricks to achieve their effects, they lend support to the idea that p53-boosting drugs could be a useful form of cancer treatment.

p53, which is mutated or inactivated by other alterations in most human cancers, is one of the most studied genes in cancer. But we still don't know whether established tumours can survive and progress if p53 is re-activated. Groups led by Scott W. Lowe and Tyler Jacks now show that even brief reactivation of endogenous p53 can cause a variety of cancers to completely regress in a handful of animal models.

The mechanism of regression appears tumour-specific. Jacks' team find that lymphoma cells are coaxed to commit suicide, whilst sarcoma cells start to senesce. Lowe's team report a novel mechanism in their liver carcinoma model whereby cell senescence appears linked to an innate immune response - certain inflammatory molecules are up-regulated, which then help to clear the cancer cells.


Scott W. Lowe (Cold Spring Harbor Laboratory, NY, USA)
E-mail: lowe@cshl.edu

Tyler Jacks (Massachusetts Institute of Technology, Cambridge, MA, USA)
E-mail: tjacks@mit.edu

Ronald A. DePinho (Harvard Medical School, Boston, MA, USA)
E-mail: ron_depinho@dfci.harvard.edu

Abstracts available online:
Paper 1.
Paper 2.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.