home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Tolerating The Gut

  January, 4 2007 0:41
your information resource in human molecular genetics
New research in the February 2007 issue of Nature Immunology reveals why the immune system remains in check and does not attack gut tissues despite being full of bacteria.

Previous work revealed microbial compounds are powerful inducers of immune responses, yet this poses a dilemma for the gut. Shannon Turley and colleagues sought to address this question. They identified specific cells found in regional lymph nodes that express proteins previously thought only to be expressed in highly specialized tissues or organs, such as the eye, gut or pancreas. The resident lymph node cells present these tissue-specific proteins to immune cells, thereby rendering them tolerant of and harmless toward the tissues expressing these proteins.

Importantly, these lymph node cells differ from conventional antigen-presenting cells that activate the immune system and are responsive to bacterial products. These findings identify another means by which the body protects itself against autoimmune attack.

Author contact:

Shannon J. Turley (Dana Farber Cancer Institute, Boston, MA, USA)
E-mail: shannon_turley@dfci.harvard.edu

Additional comment on the paper:

Michael J. Bevan (University of Washington, Seattle, WA, USA)
E-mail: mbevan@u.washington.edu

Abstract available online.

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.