home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Genetic Risk Factor For Stroke Found

  January, 25 2007 11:08
your information resource in human molecular genetics
Individuals with a particular variant of the gene PRKCH have a 40% increased risk of cerebral infarction, the most common type of stroke, according to a study to be published in the February 2007 issue of Nature Genetics.

Michiaki Kubo and colleagues examined more than 50,000 variants across the genome in more than 1,000 Japanese individuals with or without cerebral infarction. One variant in the gene PRKCH was found significantly more frequently in the individuals who had had a stroke. This variant alters the sequence of the protein encoded by PRKCH (PKC eta), which is an enzyme that modifies other proteins by attaching phosphate groups to them. The authors show that the risk variant makes the enzyme more active, and that it is abundantly expressed in a variety of different cell types in blocked arteries, which can ultimately lead to stroke. Arteries with more severe blockage tended to have higher levels of PKC eta.

Although the association was confirmed in another group of Japanese individuals with cerebral infarction, initial surveys suggest that this PRKCH variant is extremely rare in individuals of European or African descent, suggesting that it may not have a significant effect on the genetic susceptibility to stroke in non-Asian populations.

Author contact:

Michiaki Kubo (University of Tokyo, Japan)
E-mail: mkubo@ims.u-tokyo.ac.jp

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.