The authors searched for linkage disequilibrium (LD) in 137 triads with dyslexia, using markers that span the most-replicated dyslexia susceptibility region on 6p21-p22, and found association between the disease and markers within the VMP/DCDC2/KAAG1 locus. This work is presented in the Jan 2006 issue of The American Journal of Human Genetics (Vol. 78, pp. 52-62). Their expression data showed that DCDC2, which contains a doublecortin homology domain that is possibly involved in cortical neuron migration, is expressed in the fetal and adult CNS, which -- together with the hypothesized protein function -- is in accordance with findings in dyslexic patients with abnormal neuronal migration and maturation.
Department of Biosciences at Novum and Clinical Research Center, Karolinska Institute, Stockholm.
Abstract available online.
(C) The American Journal of Human Genetics.
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