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Strong Genetic Evidence of DCDC2 as a Susceptibility Gene for Dyslexia

 
  December, 14 2005 10:48
your information resource in human molecular genetics
 
     
The authors searched for linkage disequilibrium (LD) in 137 triads with dyslexia, using markers that span the most-replicated dyslexia susceptibility region on 6p21-p22, and found association between the disease and markers within the VMP/DCDC2/KAAG1 locus. This work is presented in the Jan 2006 issue of The American Journal of Human Genetics (Vol. 78, pp. 52-62). Their expression data showed that DCDC2, which contains a doublecortin homology domain that is possibly involved in cortical neuron migration, is expressed in the fetal and adult CNS, which -- together with the hypothesized protein function -- is in accordance with findings in dyslexic patients with abnormal neuronal migration and maturation.

Author contact:

Juha Kere
Department of Biosciences at Novum and Clinical Research Center, Karolinska Institute, Stockholm.

Abstract available online.

(C) The American Journal of Human Genetics.

Posted by: Tressie Dalaya


Message posted by: Trevor M. D'Souza

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