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2005-12-30
2005-12-27
- Delivering Treatment For Parkinson's
Article describes a delivery method that uses human neural progenitor cells (hNPC) which are genetically engineered to produce GDNF - a molecule that increases the survival and functioning of dopamine-neurones and decreases symptoms of the disease.
- Promoting Spinal Cord Regeneration
Retinoic acid receptor beta 2 (RARbeta2) may promote regeneration of axons in the adult rat spinal cord and improve functional recovery after spinal cord injury.
- How A Neurodegenerative Disease Gene Kills Neurons
Motor neurons secrete a mutant protein produced from this gene, setting off a chain of events that leads to cell death.
- Susceptibility To SARS Infection
A new study reports that individuals with particular combinations of genetic variants are less susceptible to infection by the SARS virus.
- Insight Into Angiogenesis
An Insight article describes many of the physiological and pathophysiological processes of both angiogenesis and lymphogenesis - the growth of new lymph vessels.
2005-12-21
2005-12-17
2005-12-14
- Wealth, Not Chemicals, Increase Breast Cancer Risk
Women who live in certain regions of the United States have a significant increase in breast cancer risk, compared with the rest of the US, but this is an effect of affluence rather than pollution.
- A Cracked Mirror In Autistic Children
Autistic children have less activation in a brain area containing neurons that are involved in understanding others' state of mind.
- Boosting Gene Expression On The X
Study finds that genes present on the X chromosome are expressed at approximately the same level as those found on non-sex chromosomes.
- Potholes Common In The Human Genome
Three new studies highlight the dramatic and very common ways in which the genomes of individual people can differ from one another.
- Tumours Prepare Sites Of Metastasis Formation
Study finds that tumours help prepare remote sites in the body for the formation of metastases.
- Viruses Need To Make Mistakes To Better Infect Hosts
Certain (RNA) viruses that copy their genome too accurately are less infectious than normal viruses.
- Epistasis Unravelled In Bardet-Biedl Syndrome
Scientists have succeeded in demonstrating and dissecting epistasis in Bardet-Biedl syndrome (BBS), an illness often characterized by obesity and learning deficits.
- How HIV Keeps Hiding
Researchers have found a way to explain how the human immunodeficiency virus (HIV) can be kept dormant and hidden in immune cells.
- Showing Strong Association with Late-Onset Alzheimer Disease
Variants in the RPS3A homologue are associated with late-onset Alzheimer disease (LOAD) and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder.
- Strong Genetic Evidence of DCDC2 as a Susceptibility Gene for Dyslexia
Study showed that DCDC2, which contains a doublecortin homology domain that is possibly involved in cortical neuron migration, is expressed in the fetal and adult CNS.
- A Testing Framework for Identifying Susceptibility Genes in the Presence of Epistasis
An efficient testing strategy called the "focused interaction testing framework" (FITF) was developed to identify susceptibility genes involved in epistatic interactions for case-control studies of candidate genes.
- Determinants of Exon 7 Splicing in the Spinal Muscular Atrophy Genes, SMN1 and SMN2
The authors report the extensive testing of the enhancer-loss and silencer-gain models by mutagenesis, RNA interference, overexpression, RNA splicing, and RNA-protein interaction experiments.
- A Germline Mutation in BLOC1S3/Reduced Pigmentation Causes a Novel Variant of Hermansky-Pudlak Syndrome (HPS8)
These findings define a novel form of human HPS (HPS8) and extend genotype-phenotype correlations in HPS.
2005-12-08
- Two telltales: a tale of a tail
Continuing his work on Histone H3 epigenetic modifications, Allis and coworkers show the regulation of pericentromeric HP1 binding by two simultaneous modifications of adjacent residues in Histone H3
2005-12-06
2005-12-05
2005-12-02
2005-12-01
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