An efficient testing strategy called the "focused interaction testing framework" (FITF) was developed to identify susceptibility genes involved in epistatic interactions for case-control studies of candidate genes. This is presented in the Jan 2006 issue of The American Journal of Human Genetics (Vol. 78, pp. 15-27). In an application to asthma case-control data from the Children's Health Study, FITF identified a significant multilocus effect between the nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase gene (NQO1), myeloperoxidase gene (MPO), and catalase gene (CAT), three genes that are involved in the oxidative stress pathway. In an independent data set consisting primarily of African American and Asian American children, these three genes also showed a significant association with asthma status.
W. James Gauderman
Department of Preventive Medicine, Division of Biostatistics, University of Southern California, Los Angeles
Abstract available online.
(C) The American Journal of Human Genetics.
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