An article in the Jan 2006 issue of The American Journal of Human Genetics (Vol. 78, pp. 78-88) provides strong evidence of linkage to late-onset Alzheimer disease (LOAD) has been observed on chromosome 10, which implicates a wide region and at least one disease-susceptibility locus. The results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder.
Departments of Psychiatry, Neurology, Biology, and Genetics, Washington University, St. Louis.
Abstract available online.
(C) The American Journal of Human Genetics.
Posted by: Tressie Dalaya
Message posted by: Trevor M. D'Souza
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