home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Chemoprevention Cocktail for Colon Cancer

 
  April, 9 2010 8:56
your information resource in human molecular genetics
 
     

Treating premalignant colorectal cells with a protein cocktail that 'persuades' them to commit cell suicide may prove a useful method of cancer chemoprevention, a Nature paper suggests.

The treatment, devised by Xiangwei Wu and colleagues, targets a molecular pathway altered early in tumorigenesis. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and all-trans-retinyl acetate (RAc) treatment caused premalignant intestinal polyp cells to commit suicide in a mouse model and a human biopsy study.

Critically, normal cells appear unaffected by the treatment, suggesting that the therapy could be beneficial in preventing human colon cancer. Also, this type of cell death is triggered by short-term, intermittent treatment cycles, so the authors hope that the potential side effects and costs associated with long-term treatment could be minimized and controlled.

Author contact:

Xiangwei Wu (MD Anderson Cancer Center, Houston, TX, USA)
E-mail: xwwu@mdanderson.org

Abstract available online.

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.