news archive June 2006

• New Clues for Treatment of Liver Cancer
  Study Implicates Two Human Genes in the Third Leading Cause of Cancer Deaths
  

• Neurons Grown from Embryonic Stem Cells Restore Function in Paralyzed Rats
  First evidence of embryonic stem cell-derived motor neuron transplants in the spinal cord connecting with muscles and partially restoring function in paralyzed animals.
  

• Mitochondrail gene linked to Rett Syndrome
  Abnormally high levels of a protein called Uqcrc1 in the brains of mouse models of Rett Syndrome cause mitochondria to work overtime, forming an energetic disequalibrium potentially toxic to neurons.
  

• NGF accelerates corneal wound healing
  In a recent online report, researchers have shown surprising corneal wounds healing acceleration by topical addition of nerve growth factor.
  

• Gene discovery points to Iron build-up as a major neuronal toxin
  Oregon Health & Science University researchers have identified the gene behind a group of rare, progressive childhood disorders caused by an abnormal buildup of iron in the brain.
  

• Tuning Out The Noise
  Over-exposure to irrelevant sounds can cause the brain to tune them out in favor of other auditory stimuli.
  
• Predicting Other's Actions Starts Young
  Babies as young as one can learn to predict the outcome of another person's actions as well as adults can.
  
• How B Cells Mature
  Researchers have identified an essential protein for B cell maturation, a process required for this immune cell to become functional.
  
• Lifeline For Aging Cells
  Scientists have found a small molecule that can be used to extend the lifespan of mammalian cells.
  
• Tumor Homing Device
  Scientists have developed a tool that can be used for diagnostic imaging and targeted therapy of tumors.
  
• Self-Renewal Understood
  Molecule identified that endows embryonic stem (ES) cells with the abilities to self-renew and to make numerous other cell types.
  
• Secret To Self-Renewal
  Analysis of the contribution of a large number of candidate genes important for regulating cell differentiation.
  
• Two Research Reports OnThe Use of Gene Therapy In The Prevention And Treatment Of Prostate Cancer.
  Two groups have published their research findings regarding the use of gene therapy in the prevention and treatment of prostate cancer.
  
• Gene Therapy For Carcinoma Of The Breast
  Specific intervention by gene therapy is a possible alternative and complementary strategy for the treatment of breast cancer.
  
• Identification of a Model for Enhanced Pain Sensitivity
  Low frequency stimulation of nociceptive C-fibers conditions spinal neurons to form a pain amplifier resembling the pathway underlying inflammatory hyperalgesia.
  
• The Sturge-Weber Foundation Announces Centers Of Excellence
  This new initiative will promote the comprehensive care necessary for treating an individual who has a port wine stain (PWS), Sturge-Weber syndrome (SWS) or Klippel-Trenaunay (KT).
  

• The molecular cause of Leukaemia: A Tax-ing business
  Scientists in Hong Kong believe they have uncovered the trigger for leukemia, a cancer of the blood that afflicts millions worldwide.
  
• Molecular Mechanism Of A Diabetes Vaccine Revealed
  Heat shock protein 60 enhances CD4CD25 regulatory T cell function via innate TLR2 signaling.
  
• The Long And The Short Of It: Expanding Small RNA Biology In Mammals
  Identification and characterization of two novel classes of small RNAs in the mouse germline
  
• European Biotech industry figures show signs of chronic under-funding
  The latest figures published today compares biotechnology sectors across some eighteen European nations and the USA.
  
• Diabetic Neuropathy: Neurons zinc-fingered into life.
  Loss of neuronal function due to diabetes is reversed in rats and humans using a novel gene therapy approach.
  

• Biogenerics and new technologies compete with 1st generation major protein products
  The US$ 32 bln market of six major protein products is enfacing competition by less costly biogenerics and by improved products via drug delivery or protein engineering technologies and even oral, small molecule solutions
  

• Enzyme Mutations Might Lead to Tumor Formation
  Lack of phosphodiesterase 11A (PDE11A, an enzyme that is involved in halting a cell’s response to hormones and stops cells from dividing is implicated in rare adrenal tumor development.
  

• SIV Vaccine Gives Hope for HIV Vaccine
  Monkeys Vaccinated Against SIV Survive Longer After Infection
  
• Accurate Diagnosis by Gene Expression Profiling
  For the first time, microscopically identical tumors from different patients are shown to be genetically distinct. This provides greater certainty about diagnosis and prognosis.
  

• Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism
  A new neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys, is decribed.
  
• Mutations In CEP290, Which Encodes A Centrosomal Protein, Cause Pleiotropic Forms Of Joubert Syndrome
  Mutations were identified in the CEP290 gene in five families with variable neurological, retinal and renal manifestations.
  
• How And When Should Genetic Tests For Cancer Be Used?
  Two experts in the use of genetic testing call for primary-care physicians and oncologists to work with medical geneticists and genetic counsellors, to identify the best clinical course of action.
  
• New Techniques For Chromosomal Damage Control
  Two articles describe tools for the detection of large-scale structural rearrangements in individual chromosomes.
  
• Urinary Tract Microbicide Prevents Infection
  When bacteria enter the urinary tract, cells there secrete antimicrobial factors to thwart infection.
  
• Tumors That Suppress Immunity
  Report shows how late-stage tumors can promote the development of 'suppressor' cells that prevent other immune cells from effectively fighting against the tumor.
  
• New Class Of Small RNAs Revealed
  Two groups of researchers have unearthed a whole new class of small RNA molecules manufactured by the mammalian genome.
  
• Enzymes Make Their Mark
  Members of a protein subfamily have been found to have demethylase activity.
  
• Virus Entry Proteins Visualized
  Researchers reveal a fresh three-dimensional look at the spike proteins on HIV's coating that allow it to bind and fuse with human cells.
  
• Yellow Card For RNA Interference
  Study shows that the long-term expression of RNA fragments in mice can end up killing the animals.
  
• Mechanism Links Protein Misfolding To Brain Disease
  Researchers identify a chemical reaction that may lead to the formation of damaging protein clumps in the brain.
  

• Gene Therapy Prevents The Onset Of Diabetic Symptoms In Mice
  Using state-of-the-art gene therapy techniques, University of Pittsburgh investigators have successfully prevented the onset of elevated blood sugar, or hyperglycemia, in diabetes-prone mice
  
• Vaccinia delivered CDA: the end for Ovarian Cancer?
  University of Pittsburgh School of Medicine researchers have used gene therapy to either completely abolish or significantly inhibit tumor progression in a mouse model of ovarian cancer
  

• Study of a Vertebrate Genome Network During Embryogenesis
  A study of the sea squirt Ciona intestinalis has yielded a four-dimensional map of genome regulation during development.
  

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