news archive genetic news - May 10, 2006

May 10, 2006

your information resource in human molecular genetics

-	Total-Genome Analysis of BRCA1/2-Related Invasive Carcinomas of the Breast Identifies Tumor Stroma as Potential Landscaper for Neoplastic Initiation Authors postulate that such a genetically unstable stroma might facilitate a microenvironment that may subsequently lead to neoplastic transformation.
-	ELMOD2 Is A Candidate Gene For Familial Idiopathic Pulmonary Fibrosis Research suggests ELMOD2 as a novel candidate gene for susceptibility in familial IPF.
-	Human Genomic Deletions Mediated By Recombination Between Alu Elements Scientists compare the reference human and chimpanzee genomes to determine the magnitude of this recombination process in the human lineage.
-	Promoter Mutations That Increase Amyloid Precursor-Protein Expression Are Associated with Alzheimer Disease The present study provides evidence that Amyloid Precursor-Protein (APP)-promoter mutations that significantly increase APP expression levels are associated with Alzheimer disease.
-	Diabetes Gene At Root Of Wider Syndrome Study shows that some of the 'Gain of function' gene mutations associated with neonatal diabetes mutations can cause a syndrome that can include developmental delay, epilepsy and muscle weakness.
-	Old Drug, New Target Scientists have identified a new target for an old drug that has been used to treat tuberculosis for over 50 years
-	Better Digs Benefit Behavior: New Neurons Not Required A new study fails to find a causal relationship between behavioral improvements and increased neurogenesis in adult mice.
-	Sensing Bacterial Infection New information on the complex interplay between host cells and bacteria during infection is reported.
-	Common Genetic Variant Associated With Prostate Cancer A common genetic marker that is found more frequently in men with prostate cancer than those without is reported in a study.
-	Nuclear Protein Controls Virus Invasion A protein in the cell's nuclear membrane regulates the ability of the HIV virus to invade human cells.
-	Parkinson's Gene Cripples Mitochondria Two teams of scientists reveal that a mutant protein implicated in inherited Parkinson's disease disables the cell's mitochondria.
-	LOX Stops The Spread Scientists identify a protein vital for metastasis that could be a new target for cancer therapies.
-	Not Without Risk A gene-therapy treatment for a severe immune deficiency could contribute to the later development of T-cell lymphomas.
-	Creation of Targeted Nanoparticles Multifunctional nanoparticles, formed via polymerization, offer a new approach to delivering anticancer drugs with a high degree of specificity.