news archive genetic news - October 19, 2005

October 19, 2005

your information resource in human molecular genetics

-	Clinical And Molecular Findings In Osteoporosis-Pseudoglioma Syndrome The authors sequenced the coding exons of the low-density lipoprotein receptor related protein 5 (LRP5) in 37 probands suspected of having autosomal recessive osteoporosis-pseudoglioma syndrome (OPPG).
-	High-Resolution Whole-Genome Association Study Of Parkinson Disease The authors performed a two-tiered, whole-genome association study of Parkinson disease (PD).
-	Children With IH And BWS Have Different Constitutional Epigenotypes Associated With Wilms Tumor Study conducted on children with Wilms tumor and Idiopathic hemihypertrophy (IH), and Wilms tumor and Beckwith-Wiedemann syndrome (BWS).
-	Nanocrystals Detect DNA Fluorescent nanocrystals - also known as quantum dots - come in handy as DNA sensors.
-	Maintaining Suppression A pair of reports show that the regulatory T (Treg) cells require the immune modulator interleukin 2 (IL-2) for their maintenance and long-term function rather than for development, as previously thought.
-	Development Of Immune Cells Associated With Allergy And Asthma Two papers describe how one type of immune cell associated with allergic inflammation and autoimmunity ultimately causes disease.
-	Malaria Protection -- Two Variants At Odds Study shows that co-inheritance of two of the most common Malaria genetic variants, which individually confer protection, may cancel the protective effects.
-	Stealing Hepatitis C's Raft Scientists have found a new drug candidate that can be used to stop the liver-damaging Hepatitis C virus (HCV) from multiplying.
-	Alzheimer's Disease - Understanding The Lipid Connection Scientists report on the function of a mysterious protein, how it affects Alzheimer's and its link to cholesterol.
-	New Methods To Derive Embryonic Stem Cells Two papers published online now provide different means of deriving human embryonic stem cells, which involves embryo destruction, from mice without eliminating a cloned embryo that has the potential to develop.
-	Abnormal Chromosome Numbers Produce Tumours two papers provide new, more direct evidence to support The idea that a failure of proper cell division produces genomic instability and promotes the development of cancer.
-	Small Molecule Inhibitor Of Cholera Discovered Increasing antibiotic resistance requires the development of novel approaches to combating infection.
-	Genetic Link To Tourette’s Syndrome Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome.
-	New Technique Adds Precision And Permanence To Gene Therapy Complete and persistent phenotypic correction of phenylketonuria in mice.
-	Faster Method To Create Antibodies For Disease Research This new method is a simple way of creating libraries of specifically binding antibodies.
-	Noise and Delays Explain Why Some Genes Oscillate in Activity Delay-induced stochastic oscillations in gene regulation.
-	Evolutionary Conservation Of A Mechanism Of Longevity From Worms To Mammals Loss of mclk1 increases cellular fitness and lifespan in mice
-	Fitting In Newly Evolved Genes Adopt A Variety Of Strategies To Remain In The Gene Pool