your information resource in human molecular genetics
2009-11-19
A*STAR of Singapore to Launch an Online Publication Promoting its Research Macmillan Scientific Communications (MSC) and Singapore's Agency for Science, Technology and Research (A*STAR) launch new open access website, A*STAR Research, to highlight some of the best research published by A*STAR's research institutions.
Understanding Schizophrenia Dysfunction of neurotransmitter signalling can cause pathological behaviour similar to that seen in schizophrenia.
The Long Shadows of Adversity Severe stress suffered at an early age can cause long-lasting changes to gene expression patterns in the mouse brain.
Damaging DNA from a Distance Medically used nanoparticles can damage the DNA of cells without crossing cellular barriers in the body.
Location, Location, Location A drug that inhibits excitatory activity in the brain can either improve or worsen the progression of Huntington's disease (HD) depending on where on neurons its targets are located.
Arthritis is Spreading A mechanism that accounts for the spreading of arthritis between joints is presented in a study.
Disrupting Lasting Memory A new protein holds the key to making long-lasting antibody responses in the body.
Re-Thinking Obesity Mutations in specific genes fully explain a small but significant subset of patients with obesity and/or type 2 diabetes while genetic factors play a key role in determining susceptibility to both disorders in the broader population.
Notch Takes a Knocking A drug that blocks a protein involved in cancer once thought 'un-blockable' has shown promise in a mouse model of leukaemia.
SARS Attacking the Ribosome A double attack by the SARS virus on host cell protein synthesis is shown in a study published online.
Heartbeat Awareness The neural pathway by which we feel stimuli originating inside our bodies -- such as our heartbeat -- is illuminated by studying an unusual patient with unique patterns of brain damage.
A Notch in Lung Arteries The common signaling molecule Notch has a role in pulmonary arterial hypertension, often caused by insufficient oxygen reaching the lungs, as reported in a study.
Layered Immunologic Memory Distinct populations of antibody-producing memory immune cells arise due to vaccination.
Possible Multiple Sclerosis Biomarker Small molecules of RNA are positively associated with disease relapses in multiple sclerosis (MS) in patients according to a report published online.
Age-Related Sperm Mutations Associated with Testicular Tumor A rare type of benign testicular tumor is associated with genetic mutations arising from paternal age-effect mutations, which are inherited from fathers that are older than the population mean.
CRLF2 Defects in Down Syndrome-Associated Leukemia A chromosomal alteration that fuses the P2RY8 and CRLF2 genes is found in individuals with B-progenitor acute lymphoblastic leukemia (ALL) and ALL associated with Down syndrome (DS).
Ribosome Reactions Two studies discuss new fundamental properties of the ribosome as well as new ways to manipulate the ribosomal machinery.
Intravital Imaging Reveals Regulation of Metastasis Activation of a specific intracellular signalling cascade determines whether cancer cells spread as single cells or as a collective unit, and whether they invade via the lymph system or blood.
Stem Cells Help Study of Infertility Genes Researchers have tracked and isolated germ cells derived from human embryonic stem cells and studied which genes are involved in their formation.
Synapse, So What? Study shows that certain neurons can exert their inhibitory effects without using the specialized intercellular junctions.
Cancer Link to Microenvironment A key signalling pathway that operates in mammary gland connective tissue cells helps to suppress the development of mammary tumours.
Repairing Memory after a Sleepless Night The cognitive deficits caused by sleep deprivation may be reversible by reducing the concentration of a specific enzyme in the hippocampus of the brain.