More rapid HIV disease progression occurs in individuals who have a specific genetic risk factor, according to a new study published online in Nature Immunology. A team of HIV researchers led by Sunil Ahuja studied a risk factor that significantly predicts HIV disease outcome. Individuals who have certain combinations of the two genes CCR5 and CCL3L1 are much more likely to have reduced immune responses and greater decline in numbers of CD4+ T immune cells, two hallmarks of progressive HIV disease.
The significance of the findings is two-fold. Previous work indicated that the influence of the two genes was much more limited that the new data indicate. These findings suggest a means to more effectively predict the course of HIV disease.
Sunil Ahuja (University of Texas Health Science Center, San Antonio, TX, USA)
Abstract available online.
(C) Nature Immunology press release.
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