home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Genetic Risk Factor For Colorectal Cancer

 
  October, 31 2007 20:29
your information resource in human molecular genetics
 
     
Common variants in the gene SMAD7 are associated with an increased risk of colorectal cancer, reports a study to be published online in Nature Genetics.

Richard Houlston, Ian Tomlinson and colleagues carried out a genome-wide association study, genotyping more than 500,000 single nucleotide polymorphisms (SNPs) in several thousand individuals with familial colorectal cancer, as well as controls.

Three SNPs in SMAD7 were associated with increased risk of the disease in an initial sample, as well as in three replication sample sets, with a high degree of statistical significance. SMAD7 is an intracellular molecule that inhibits the TGF-beta pathway, which is involved in cell-cell signalling events in a wide range of tissues, including the colon. Although variation in SMAD7 contributes only modestly to risk of colorectal cancer -- it contributes to approximately 15% of such cancers in the general population, and less than 1% of the familial risk -- this result suggests, together with other recent data, that common variants of modest effect underlying this disease exist and can be discovered.

Author contacts:

Richard Houlston (Institute of Cancer Research, Sutton, UK)
E-mail: richard.houlston@icr.ac.uk

Ian Tomlinson (Cancer Research UK, London)
E-mail: ian.tomlinson@cancer.org.uk

Abstract available online.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.