home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

The Genetics Of Human Height

 
  September, 5 2007 0:35
your information resource in human molecular genetics
 
     
A variant in a gene called HMGA2 is associated with differences in adult and childhood height in the general population, reports a study to be published online in Nature Genetics. This is the first such common variant to be reproducibly associated with human stature, and likely heralds a new wave of studies associating genetic variation with non-disease-related complex traits in humans.

Studies of twins have shown that up to 90% of the normal variation in human height is due to genetic variation, with such variants likely to be distributed among a large number of genes. A large consortium of investigators led by Timothy Frayling, Joel Hirschhorn, and Mark McCarthy carried out a genome-wide association study of nearly 5,000 individuals, and found two variants very close to HMGA2 to be associated with variation in height. A follow-up study of more then 19,000 individuals confirmed the association.

HMGA2 is an excellent candidate to be associated with height, as rare, severe mutations in the gene cause dramatic alterations of body size in mice and humans. Although the effect of these common HMGA2 variants is small-- explaining approximately 0.3% of population variation in height, or approximately 0.4 cm increased height per copy in an individual-- the success of the study suggests that additional genes will soon be associated with height and other visible traits in humans.

Author contact:

Timothy Frayling (Peninsula Medical School, Exeter, UK)
E-mail: tim.frayling@pms.ac.uk

Abstract available online.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.