home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Restraining Allergic Responses

  September, 5 2007 0:37
your information resource in human molecular genetics
A cellular process crucial for preventing allergy is presented in a paper published online in Nature Immunology.

Certain varieties of immune cells release interleukin 4, a protein that, upon binding to its receptor, triggers signals that promote hallmark features of allergy. Yoshinori Fukui and colleagues show that interleukin 4 receptors expressed on the surface of immune cells called T cells are quickly internalized, directed along the complex network of protein 'fibres' that support T cell structure and shape, and ultimately routed into cellular compartments for degradation. This 'harness' on interleukin 4 expression is interrupted in T cells lacking Dock2, a protein responsible for regulating the 'trafficking' of internalized cargo. As a result Dock2-deficient T cells display excessive amounts of interleukin-4 receptors and Dock2-deficient mice suffer from spontaneous allergic inflammation. Whether Dock2 regulates the intracellular fate of other T cell surface proteins remains for future investigations.

Author contact:

Yoshinori Fukui (Kyushu University, Fukuoka, Japan)
E-mail: fukui@bioreg.kyushu-u.ac.jp

Abstract available online.

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.