home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

A Three-In-One Approach To Cancer Vaccines

 
  September, 5 2007 0:34
your information resource in human molecular genetics
 
     
A single chemical structure that incorporates three vaccine components could prove powerful in treating cancer, according to a paper in the October 2007 issue of Nature Chemical Biology. Sugars are often highly expressed on the outside of cancer cells, and eliciting an immune response to these sugars could be an important vaccine strategy.

Previous attempts to develop anticancer vaccines against these overexpressed sugars have involved 'two-component' vaccines, which combine molecules that can induce antibody production by two different routes into a single chemical entity. However, these vaccines require very high levels of adjuvants-- additional chemicals that are used to boost the immune response being elicited by the vaccine.

Geert-Jan Boons and colleagues have now developed a 'three-component' vaccine that chemically links the adjuvant to two other vaccine components. Chemically connecting these three vaccine pieces proved to be exceptionally powerful in inducing an immune response in mice. This vaccine strategy can now be tested for its ability to combat cancer, and the three-component approach could be applied to other vaccine targets.

Author contact:

Geert-Jan Boons (University of Georgia, Athens, GA, USA)
E-mail: gjboons@ccrc.uga.edu

Abstract available online.

(C) Nature Chemical Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.