|
|
|
A single chemical structure that incorporates three vaccine components could prove powerful in treating cancer, according to a paper in the October 2007 issue of Nature Chemical Biology. Sugars are often highly expressed on the outside of cancer cells, and eliciting an immune response to these sugars could be an important vaccine strategy.
Previous attempts to develop anticancer vaccines against these overexpressed sugars have involved 'two-component' vaccines, which combine molecules that can induce antibody production by two different routes into a single chemical entity. However, these vaccines require very high levels of adjuvants-- additional chemicals that are used to boost the immune response being elicited by the vaccine. Geert-Jan Boons and colleagues have now developed a 'three-component' vaccine that chemically links the adjuvant to two other vaccine components. Chemically connecting these three vaccine pieces proved to be exceptionally powerful in inducing an immune response in mice. This vaccine strategy can now be tested for its ability to combat cancer, and the three-component approach could be applied to other vaccine targets. Author contact: Geert-Jan Boons (University of Georgia, Athens, GA, USA)
E-mail: gjboons@ccrc.uga.edu Abstract available online. (C) Nature Chemical Biology press release.
Message posted by: Trevor M. D'Souza
|
|
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...
|