home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Understanding Why H5N1 Is So Lethal

  September, 13 2006 10:01
your information resource in human molecular genetics
A study of patients who became infected with H5N1 in Vietnam reveals clues as to why the avian influenza virus is so virulent, according to research to be published in the October 2006 issue of Nature Medicine.

Menno de Jong and colleagues compared viral levels and effects on the immune system in one group of patients infected with H5N1 and another group infected with two types of human flu virus. The patients with H5N1 infection had much higher levels of viral load in the throat than the patients infected with the human virus; markers of viral load were highest in the H5N1 patients who died. Virus could also frequently be detected in the blood of H5N1 patients but only in those who died. The authors found that high levels of H5N1 virus triggered a release of some inflammatory cytokines; levels of cytokines correlated with levels of viral load and were highest in the patients who died. Fatal H5N1 infection was also associated with a loss of lymphocytes in the peripheral blood.

The authors suggest these findings support the view that the H5N1 virus replicates to much higher levels than the human virus and that the high levels of the virus trigger an overwhelming inflammatory response that contributes to lung dysfunction and eventual death. They also propose that it will be important to diagnose H5N1 infection early and administer antivirals quicky, nipping viral replication in the bud and preventing the intense inflammation.

Author contact:
Menno de Jong (Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam)
E-mail: dejongmd@gmail.com

Abstract available online.

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.