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2006-09-27
2006-09-19
2006-09-13
- Identification Of The Gene Encoding The Enzyme Deficient In Mucopolysaccharidosis IIIC (Sanfilippo Disease Type C)
Gene Encoding The Enzyme Deficient In Mucopolysaccharidosis IIIC (Sanfilippo Disease Type C) identified.
- A Deleterious Mutation in SAMD9 Causes Normophosphatemic Familial Tumoral Calcinosis
Mutation in SAMD9 Causes Normophosphatemic Familial Tumoral Calcinosis.
- Mutations In CABP4, The Gene Encoding The Ca2+-Binding Protein 4, Cause Autosomal Recessive Night Blindness
Mutations in CABP4, the gene encoding the Ca2+-Binding Protein 4, cause autosomal recessive night blindness
- AAV-Mediated Expression Of CNTF Promotes Long-Term Survival And Regeneration Of Adult Rat Retinal Ganglion Cells
Study compares the effects of intravitreal injection of bi-cistronic AAV-2 vectors encoding enhanced GFP and either CNTF, BDNF or GAP43 on RGC survival and regeneration.
- Adenoviral Expression Of XIAP Antisense RNA Induces Apoptosis In Glioma Cells And Suppresses The Growth Of Xenografts In Nude Mice
Infection of malignant glioma cells and several other tumor cell lines with adenoviruses encoding antisense RNA to X-linked IAP (XIAP) depletes endogenous XIAP levels and promotes global caspase activation and apoptosis.
- Gene Therapy Progress And Prospects: Non-Viral Gene Therapy By Systemic Delivery
Review focuses on the progress made over the last 2 years, and some future prospects for gene delivery.
- A Novel Trick Of An Old Friend
A form of the well-known protein, p53, appears to promote brain nerve fibre regeneration in a mouse model.
- A Novel Trick Of An Old Friend
A form of the well-known protein, p53, appears to promote brain nerve fibre regeneration in a mouse model.
- Attention Can Impair Visual Perception
Study reports that sustained attention actually worsens the perception of some visual stimuli.
- Understanding Why H5N1 Is So Lethal
A study of patients who became infected with H5N1 in Vietnam reveals clues as to why the avian influenza virus is so virulent.
- Regulating The Immune Response
A protein called SARM -- SAM and ARM-containing protein -- helps to regulate the immune response against invading pathogens.
- Excess Wnt Kills
Excessive stimulation of bone marrow stem cells in mice leads to severe anemia and ultimately death.
- FDA Spearheads Microarray Quality Control Project
A major, multi-center study comparing the reliability of an emerging technology for measuring human gene expression is reported.
- RNA Interference Screens Questioned
Many genes identified as targets of RNA interference (RNAi) in the fruitfly Drosophila could be false.
- APTX Helps Mend Broken DNA
Mutations in the gene aprataxin (APTX) are responsible for the rare neurological disorder ataxia oculomotor apraxia-1 (AOA1).
- Understanding Ageing
Three papers help answer why progenitor cells gradually lose their ability to divide and generate new cells as they grow old.
- Two Faces Of p53
Research paper challenges the conventional view of p53, a central protein in protecting against cancer.
2006-09-07
2006-09-05
- A Regulatory Role for the Estrogen Receptor Beta Isoforms
Seemingly inactive estrogen receptors beta-2, -4, and -5 form heterodimers with the active beta-1 isoform, thereby enhancing its effectiveness as a type I nuclear receptor. But in so doing, they bestow it with properties of a type II nuclear receptor.
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