|
|
|
A protein called SARM -- SAM and ARM-containing protein -- helps to regulate the immune response against invading pathogens, according to a report in the October issue of Nature Immunology.
SARM is a member of the so-called 'TIR' -- Toll-interleukin 1 receptor -- adaptor protein family. All other members of this family help to transmit signals triggered by pathogens to promote an immune response. Andrew Bowie and colleagues now show that in contrast to the other four members of the TIR family, SARM unexpectedly blocks rather than promotes signals triggered by pathogens. The identification of SARM as a regulator, rather than a promoter, of the immune response may prove useful therapeutically. Author contact: Andrew Bowie (Trinity College, Dublin, Ireland)
E-mail: agbowie@tcd.ie Abstract available online. (C) Nature Immunology press release.
Message posted by: Trevor M. D'Souza
|
|
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...
|