home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Regulating The Immune Response

 
  September, 13 2006 9:59
your information resource in human molecular genetics
 
     
A protein called SARM -- SAM and ARM-containing protein -- helps to regulate the immune response against invading pathogens, according to a report in the October issue of Nature Immunology.

SARM is a member of the so-called 'TIR' -- Toll-interleukin 1 receptor -- adaptor protein family. All other members of this family help to transmit signals triggered by pathogens to promote an immune response. Andrew Bowie and colleagues now show that in contrast to the other four members of the TIR family, SARM unexpectedly blocks rather than promotes signals triggered by pathogens. The identification of SARM as a regulator, rather than a promoter, of the immune response may prove useful therapeutically.

Author contact:

Andrew Bowie (Trinity College, Dublin, Ireland)
E-mail: agbowie@tcd.ie

Abstract available online.

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.