A protein called SARM -- SAM and ARM-containing protein -- helps to regulate the immune response against invading pathogens, according to a report in the October issue of Nature Immunology.
SARM is a member of the so-called 'TIR' -- Toll-interleukin 1 receptor -- adaptor protein family. All other members of this family help to transmit signals triggered by pathogens to promote an immune response. Andrew Bowie and colleagues now show that in contrast to the other four members of the TIR family, SARM unexpectedly blocks rather than promotes signals triggered by pathogens. The identification of SARM as a regulator, rather than a promoter, of the immune response may prove useful therapeutically.
Andrew Bowie (Trinity College, Dublin, Ireland)
Abstract available online.
(C) Nature Immunology press release.
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