home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

APTX Helps Mend Broken DNA

  September, 13 2006 9:49
your information resource in human molecular genetics
Mutations in the gene aprataxin (APTX) are responsible for the rare neurological disorder ataxia oculomotor apraxia-1 (AOA1). Stephen West and his colleagues show in a paper published online by Nature that this protein is involved in DNA repair, and suggest that AOA1 may be caused by the gradual accumulation of unrepaired breaks in the DNA of neuronal cells.

Aprataxin associates with other DNA repair proteins, but it was not known whether it has a direct role in the process of DNA repair. The researchers used purified extracts containing normal and mutant aprataxin protein to show that the protein helps join together double-strand breaks in DNA induced by reactive oxygen molecules, or free radicals. Specifically, it removes chemical groups called adenylates from one of the DNA ends to allow them to be stitched back together.

Author contact:

Stephen West (Cancer Research UK, London, UK)
E-mail stephen.west@cancer.org.uk

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.