home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Understanding Ageing

  September, 13 2006 9:48
your information resource in human molecular genetics
Three papers published online in Nature help answer a fundamental question in mammalian ageing: why progenitor cells gradually lose their ability to divide and generate new cells as they grow old. They show that a protein called p16INK4a limits the regenerative abilities of such cells in ageing bone marrow, brain and pancreas.

p16INK4a is a protein involved in cell cycle control, and is already known to suppress cancer. The teams show that the activity of the p16INK4a gene increases as progenitor cells in the three mouse tissues lose their ability to self-renew. Sean Morrison and his colleagues studied neural progenitors in the mouse forebrain; Norman Sharpless and his team studied progenitors in the pancreatic islets that make insulin-secreting beta-cells; and David Scadden and his group examined haematopoietic bone marrow cells that make blood.

The teams genetically engineered mice that lacked p16INK4a and then examined them when they reached old age, some 18 months later. Progenitor cells in these mice cling onto their youth - they do not show the normal age-dependent decline in proliferation.

The work also suggests that type 2 diabetes might partly be explained by the failure of the pancreatic islets to renew with ageing, and perhaps that blocking this protein in certain tissues might combat certain effects of ageing.


Author paper [1]
Sean Morrison (University of Michigan, Ann Arbor, MI, USA)
E-mail: seanjm@umich.edu

Author paper [2]
Norman Sharpless (University of North Carolina School of Medicine,
Chapel Hill, NC, USA)
E-mail: NES@med.unc.edu

Author paper [3]
David Scadden (Harvard Stem Cell Institute, Boston, MA, USA)
E-mail: scadden.david@mgh.harvard.edu

N&V author
Judith Campisi (Lawrence Berkeley National Laboratory, Berkeley, CA, USA)
E-mail: jcampisi@lbl.gov

Abstracts available online:
Paper 1.
Paper 2.
Paper 3.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.