home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Anti-Ageing Effect Of Protein Duo

  July, 25 2007 17:01
your information resource in human molecular genetics
Boosting the levels of two proteins in mice suppresses cancer and delays ageing, a Nature paper reveals.

The tumour suppressor protein p53 and one of its regulators, ARF, are known to be involved in the detection and elimination of cellular damage. Manuel Serrano and colleagues now show that mice with an increased, but otherwise normally regulated, dose of the two proteins are resistant to the development of cancers. It comes as no surprise therefore, that these animals have an extended lifespan compared to wild-type mice.

Remarkably, however, on average these animals outlive their normal counterparts even when animals dying of cancer are removed from the survival curves. Moreover, various biological and molecular markers of ageing indicate that these mice stay younger for longer. The researchers conclude that boosting endogenous ARF/p53 activity provides a robust anti-oxidant effect that not only suppresses cancers, but also delays ageing.


Manuel Serrano (Spanish National Cancer Research Center, CNIO, Madrid, Spain)
E-mail: mserrano@cnio.es

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.