news archive July 2007

• Probing For Prions
  A rapid and very sensitive technique for the detection of infectious prion proteins is reported online.
  
• A Genetic Step For Restless Leg Syndrome
  New genetic insight into the basis of restless leg syndrome (RLS) is reported online.
  
• Genetic Risk Factor For Gallstone Disease
  A variant in a gene encoding a cholesterol transporter of the liver more than doubles the risk of gallstone disease.
  
• Two Anticancer Drugs Target The Spliceosome
  Scientists have identified the cellular target of two important anticancer molecules as a component of the spliceosome.
  
• Anti-Ageing Effect Of Protein Duo
  Boosting the levels of two proteins in mice suppresses cancer and delays ageing.
  
• Potential Type 1 Diabetes Gene Found
  The discovery of gene newly implicated in the pathogenesis of type 1 diabetes may boost the development of predictive tests.
  

• On Target: Il-6 activation by Ras in cancer
  Scientists identify the cytokine IL6 as a new chemotherapeutic target for Ras-driven cancers
  

• Human Antibodies that Block Human and Animal SARS Viruses Identified
  Two human antibodies that bind to a region on the SARS virus’ spike glycoprotein that is called the receptor binding domain (RBD)have been found.
  
• Ability to Listen to Two Things at Once Is Largely Inherited
  A recent twin study reveals that your ability to listen to a phone message in one ear while a friend is talking into your other ear and comprehend what both are saying is an important communication skill that is heavily influenced by your genes.
  

• Ago2 and Hematopoiesis
  mRNA destructive activity of Ago2 is not required for blood cell development.
  
• The Flip Side of p27
  Scientists uncover new roles for p27 in oncogenesis and stem cell expansion
  

• Eyes May Foreshadow Cardiovascular Disease
  Structural changes in the eye's blood vessels are associated with a higher body mass index (BMI) and could signal the onset of other cardiovascular risk factors such as diabetes or hypertension.
  
• Complete Knockdown Of Gene Inhibits HIV Infection
  The complete suppression of the gene CCR5 in white blood cells leads to a stronger protection against HIV.
  
• Therapeutic RNA Interference In Neurodegenerative Disease
  Scientists consider how RNA interference (RNAi) technology might be exploited to treat neurodegenerative diseases that are currently incurable, such as Huntington's disease, Alzheimer's disease and spinocerebellar ataxia.
  
• Growth Factor Reinforces Cocaine Addiction
  Release of a growth factor in the nucleus accumbens - a brain area mediating reward - is necessary for the development and relapse of cocaine addiction.
  
• The Amygdala And Persistent Behaviour In Addiction
  Neurons in part of the brain known as the basolateral amygdala mediate persistent behaviour induced by cocaine exposure.
  
• Male Pheromone Stimulates Neurogenesis In The Female Brain
  Pheromone signals from dominant males stimulate the production of new neurons in the olfactory bulb and hippocampus of the brain in female mice.
  
• Spermicide Might Favour HPV Infection
  A molecule widely used in vaginal spermicides could increase genital transmission of the human papilomavirus (HPV).
  
• The Stress Of Gaining Weight
  A hormone involved in the neural control of feeding might also be linked to stress-induced obesity.
  
• Arresting Autoimmunity
  Study reveals how T lymphocytes survive to induce several types of autoimmune disease, including multiple sclerosis.
  
• Common Genetic Risk Variant For Colorectal Cancer
  A common variant on chromosome 8 that predisposes to prostate cancer also confers risk of colorectal cancer.
  
• Genetic Link Between Prostate Cancer And Type 2 Diabetes
  Two variants on chromosome 17 confer risk of prostate cancer, one of which also protects against type 2 diabetes.
  
• Hsp90 Inhibitors Allow Small Cell Lung Cancer To Die
  Scientists describe the role played by a protective protein called Hsp90 in maintaining the malignant state of small cell lung cancer cells.
  
• Protein Function From First Principles
  Scientists have identified the function of a previously uncharacterized enzyme using a novel approach.
  
• RNAi Resource
  A resource that could change the very nature of genetic research on fruitflies is published.
  
• Newly Discovered Protein May Help Treat Parkinson's?
  A new neuron-nourishing protein that may prove useful for treating Parkinson's disease is revealed.
  
• New Cancer Mutation Found
  A newly identified genetic mutation found in several types of cancer makes cultured cells cancerous and induces leukaemia in mice.
  
• Variation Associated With Childhood Asthma
  Variations in expression of a gene called ORMDL3 are associated with the development of childhood asthma.
  
• Chromatin Modification Maps And Cell State
  Paper describes the generation of genome-wide maps of chromatin modification in mammalian cells.
  
• Mutations Increase Risk Of Common Heart Problem
  Two mutations have been implicated in the most common heart rhythm abnormality.
  
• New Type Of Stem Cell Derived
  A new type of rodent embryonic stem (ES) cell has been derived that is more similar to human ES cells than current mouse alternatives.
  

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