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Potential Type 1 Diabetes Gene Found

 
  July, 25 2007 17:00
your information resource in human molecular genetics
 
     
The discovery of gene newly implicated in the pathogenesis of type 1 diabetes may boost the development of predictive tests. The findings are published online in Nature.

Hakon Hakonarson and colleagues performed a genome-wide association study on DNA from more than 500 patients with type 1 diabetes and more than 1,000 controls. As well as confirming associations with known type-1-diabetes-related genes, the team spotted a link between the condition and a gene called KIAA0350. It is thought that the gene encodes a sugar-binding C-type lectin, a multi-talented group of proteins whose functions include carbohydrate recognition and cell adhesion.

Type 1 diabetes is a highly debilitating autoimmune disease that primarily affects children. By the time of clinical diagnosis, most of the insulin-producing beta cells have been destroyed, which makes genetic prediction and prevention especially important.

Author contact:

Hakon Hakonarson (Children's Hospital of Philadelphia, PA, USA)
E-mail: hakonarson@chop.edu

Abstract available online.

(C) Nature press release.


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