home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

RBP4 Protein Contributes To Diabetes

 
  July, 26 2005 11:02
your information resource in human molecular genetics
 
     
As the number of people with type 2 diabetes continues to rise, researchers are working to understand exactly why this is.

Increasing obesity rates have put more people at risk of developing diabetes, and now we have a new clue as to how. In an article appearing in the 21 July 2005 issue of Nature (Vol. 436, No. 7049, pp. 354-360), researchers describe how a protein called RBP4, which is released by fat tissue, causes insulin resistance in mice. Elevated levels of this protein had previously been detected in diabetes patients, but a causal link was not suspected.

Barbara Kahn and her colleagues found that raising levels of RBP4 causes insulin resistance, whereas lowering it has the opposite effect. They also discovered that insulin-sensitizing medications lowered the level of this protein. The scientists suggest that lowering RBP4 levels might serve as a viable strategy for treating type 2 diabetes.

"Yang and colleagues' findings may provide the solution to a long-standing paradox in diabetes research," write Deborah Muoio and Christopher Newgard in a related News & Views piece.

CONTACT

Barbara B. Kahn (Beth Israel Deaconess Medical Center / Harvard Medical School, Boston, MA, USA)
E-mail: bkahn@bidmc.harvard.edu

Christopher Newgard (Duke University, Durham, NC, USA)
E-mail: newga002@mc.duke.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.