New Compound May Decrease Vision Loss In Diabetes First clinical trial evaluating effect of PKC-beta inhibitor on diabetes-induced eye complications raises hopes for preserving sight in some individuals
Synaptic Damage In Alzheimer Disease Study suggests a molecular mechanism that could shed light on how Alzheimer disease produces the dementia and memory loss that are its major symptoms.
Interfering With HIV Scientists have found a molecule that interferes with the formation of infectious Human immunodeficiency virus (HIV) particles.
Tickling Nerves Prevents Inflammation Stimulation of nicotinic acetylcholine receptors (nAChRs), which are found on both nerves and immune cells, can initiate a program that shuts down the inflammatory machinery of immune cells.
Developing New Cellular Modules Scientists report the development of new mRNA-ribosome pairs that function orthogonally - in parallel with, but without affecting, endogenous ribosomal translation.
A Selective Gene-Repression Probe Researchers have identified a small-molecule inhibitor that may be a valuable tool for gene-repression studies.
DNA Adopts A New Fold Researchers report a new structure formed by a DNA sequence that is known to be important in cancer development.
Small Doses Go A Long Way Researchers have found a way of delivering small RNA molecules targeted against the hepatitis B virus at low doses.
A Structure Of Antidepressants' Binding Sites Scientists have now captured the crystal structure of a bacterial sodium chloride-dependent transporter, which moves leucine across membranes.
RBP4 Protein Contributes To Diabetes Researchers describe how a protein called RBP4, which is released by fat tissue, causes insulin resistance in mice.
Cause Of Heart Valve Disease Identified Researchers have identified the genetic mutations that can produce a spectrum of cardiac abnormalities involving calcification of the aortic valve.
Nitric Oxide Inhalation Therapy for Preterm Found Questionable Inhaled nitric oxide therapy is effective for treating full term infants with lung complications; however, in preterm infants it does not reduce chances for death or further lung problems.
SARS Receptor Identified In Vivo Angiotensin-converting enzyme 2 (ACE2) is a crucial receptor of the severe acute respiratory syndrome (SARS) virus in vivo.
Growth Factor Brings Back Hope To Parkinson Patients Infusion of glial cell line-derived neurotrophic factor (GDNF) into the brain of people with Parkinson disease induces the growth of nerve fibers in one of the brain regions affected by this disorder.
Adding up Tolls for Immune Cell Researchers show that human immune cells integrate multiple signals obtained by 'tasting' their microbial invader through sensors known as Toll-like receptors (TLRs).
An Amplified Difference In Melanoma Cells Scientists have found a distinct amplification of the gene encoding MITF (microphthalmia-associated transcription factor) in melanoma cells.
Cigarette Brain Boost Inseparable From Addiction New research in mice shows that the same brain system is involved in both stimulation and addiction, meaning that the two are unlikely to be separable.
A Global View Of Cancer Specific modifications of histones are linked to changes in gene expression, and have been found to be altered in cancer.
The Dynamics Of A Human Cancer Revealed A team of researchers has developed a mathematical model based on the biology of blood cell formation to describe how certain cancer cells respond to a molecularly targeted therapy.
Protein Structure Initiative Advances to Rapid Production Phase With the announcement of 10 new research centers, the Protein Structure Initiative (PSI) launches the second phase of its national effort to find the three-dimensional shapes of a wide range of proteins.