home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Drug Shows Promise For Strengthening Hearts

  July, 26 2005 11:00
your information resource in human molecular genetics
A new drug offers hope for warding off heart failure associated with Duchenne muscular dystrophy. A study shows that the chemical, called poloxamer 188, strengthens heart muscle cells, making them less likely to break under strain. Researchers led by Joseph Metzger studied individual heart muscle cells, or cardiac myocytes, from mice lacking the protein dystrophin, a deficiency that causes muscular dystrophy. These cells were more likely to break when stretched, because holes in the cell membrane allow in more calcium ions, which in turn trigger abnormal contraction that rips the cell apart.

Cells treated with poloxamer 188, however, did not show such weakness, the researchers report in a paper to be published online in Nature on 17 July. Mice with muscular dystrophy were also saved from stress-induced heart failure when treated with the drug. The chemical therefore shows promise for treating human sufferers, the authors add, but medical trials will be needed to determine the appropriate dose and ensure that the drug is safe.

Author contact:

Joseph Metzger (University of Michigan, Ann Arbor, MI, USA)
E-mail: metzgerj@umich.edu

(C) Nature press release

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.