home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Self-Renewal Understood

  June, 21 2006 7:49
your information resource in human molecular genetics
A paper to be published online by Nature (Vol. 441, No. 7095)identifies a molecule that endows embryonic stem (ES) cells with their revered properties: the ability to self-renew and 'pluripotency', the ability to make numerous other cell types. Molecules such as this might one day be used to convert a patient's regular, somatic cell into an ES cell, perhaps avoiding the ethically contentious extraction of ES cells from human embryos.

Stem-cell biologists know that fusing an ES cell with a somatic cell can bestow the latter with pluripotency. Austin Smith and his colleagues show that a protein called Nanog, which is manufactured in young embryos, is responsible: they showed that mouse ES cells making extra Nanog protein can convert neural stem cells into pluripotent cells at a much higher efficiency. They propose that Nanog directs the ES cell machinery to erase old patterns of gene activity and install new pluripotent ones.


Austin Smith (University of Edinburgh, UK)
E-mail: austin.smith@ed.ac.uk

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.