news archive May 2006

• Spotty mice flout Mendels Law
  Scientists say they have demonstrated that animals can defy the laws of Mendelian inheritance. Researchers found that mice can pass on traits to their offspring even if the gene behind those traits is absent.
  

• Gaining more hen-sight into Lebers Congenital Amaurosis
  University of Florida scientists have delivered a gene through an eggshell to give sight to a type of chicken normally born blind.
  
• Personalized Treatment Trial for Breast Cancer
  Trial Designed to find the most effective approach to cancer treatment with the fewest side effects for women with early-stage breast cancer.
  
• In Elderly, The More Flu Vaccine The Better
  U.S. Study Finds Higher Dose of Flu Vaccine Improves Immune Response in the Elderly
  
• Fluid Management Study in Lung Injury Shows Less Is More
  Study Answers Long-Debated Questions on Fluid Management in Critical Care
  
• Inducible Regulation Of Runx2-Stimulated Osteogenesis
  Researchers describe a retroviral system to deliver the Runx2 osteoblastic transcription factor.
  
• Mosaic Vectors For Efficient Vector Purification And Targeting To Vascular Endothelial Cells
  Adeno-associated virus (AAV) 1 has shown the most promise among the AAV vectors for the transduction of vascular endothelial cells.
  
• RNAi Therapeutics: Can siRNAs Conquer SARS?
  Report on a new approach to coping with emerging infectious diseases, that uses small interfering (si)RNAs.
  
• Regeneration Of Injured Optic Nerve
  A treatment applied three days after optic nerve injury greatly improves regeneration.
  
• New Techniques For Chromosomal Damage Control
  Two articles describe tools for the detection of large-scale structural rearrangements in individual chromosomes.
  
• Gene Variant Associated With Type 1 Diabetes
  A new gene variant associated with risk of type 1 diabetes is reported.
  
• Mothballs Link Cell Death And Cancer
  Components of the humble mothball are carcinogens because they block cell suicide.
  
• SUMO Switches Metastasis On And Off
  New players in the process of metastasis of cancer cells are described.
  
• Immune Molecule Fuels Tumours
  A molecule central to chronic autoimmune diseases also promotes the incidence and growth of tumours.
  
• Chromosome 1 Completes The Set
  Report on the finished DNA sequence of human chromosome 1.
  
• Novel Antibiotic Fights Hospital Killers
  Team of researchers discovers a potent natural antibiotic that kills many Gram-positive bacteria.
  
• A New Signal For Axon Regeneration Is Discovered
  Oncomodulin, released from macrophages, stimulates axon regeneration as part of the response to optic nerve injury.
  

• The next generation of interferons needs improvement in efficacy and safety
  The interferon alpha market is smaller than the interferon beta market, but is characterized by far more products and R&D projects.
  

• Tumor Stem Cells Turn Out to be Good Models for Brain Tumor Research
  Glioblastoma tumor stem cell lines offer a powerful new tool for research and treatment.
  
• Prozac’s Target Revealed
  Neural stem cells provide information about how cells become reactive to Prozac (fluoxetine).
  
• A Loose Fit May Be The Best Bet In Drug Design
  Common wisdom challenged as loosely connecting ligands at receptor sites lead to better signalling.
  

• Total-Genome Analysis of BRCA1/2-Related Invasive Carcinomas of the Breast Identifies Tumor Stroma as Potential Landscaper for Neoplastic Initiation
  Authors postulate that such a genetically unstable stroma might facilitate a microenvironment that may subsequently lead to neoplastic transformation.
  
• ELMOD2 Is A Candidate Gene For Familial Idiopathic Pulmonary Fibrosis
  Research suggests ELMOD2 as a novel candidate gene for susceptibility in familial IPF.
  
• Human Genomic Deletions Mediated By Recombination Between Alu Elements
  Scientists compare the reference human and chimpanzee genomes to determine the magnitude of this recombination process in the human lineage.
  
• Promoter Mutations That Increase Amyloid Precursor-Protein Expression Are Associated with Alzheimer Disease
  The present study provides evidence that Amyloid Precursor-Protein (APP)-promoter mutations that significantly increase APP expression levels are associated with Alzheimer disease.
  
• Diabetes Gene At Root Of Wider Syndrome
  Study shows that some of the 'Gain of function' gene mutations associated with neonatal diabetes mutations can cause a syndrome that can include developmental delay, epilepsy and muscle weakness.
  
• Old Drug, New Target
  Scientists have identified a new target for an old drug that has been used to treat tuberculosis for over 50 years
  
• Better Digs Benefit Behavior: New Neurons Not Required
  A new study fails to find a causal relationship between behavioral improvements and increased neurogenesis in adult mice.
  
• Sensing Bacterial Infection
  New information on the complex interplay between host cells and bacteria during infection is reported.
  
• Common Genetic Variant Associated With Prostate Cancer
  A common genetic marker that is found more frequently in men with prostate cancer than those without is reported in a study.
  
• Nuclear Protein Controls Virus Invasion
  A protein in the cell's nuclear membrane regulates the ability of the HIV virus to invade human cells.
  
• Parkinson's Gene Cripples Mitochondria
  Two teams of scientists reveal that a mutant protein implicated in inherited Parkinson's disease disables the cell's mitochondria.
  
• LOX Stops The Spread
  Scientists identify a protein vital for metastasis that could be a new target for cancer therapies.
  
• Not Without Risk
  A gene-therapy treatment for a severe immune deficiency could contribute to the later development of T-cell lymphomas.
  
• Creation of Targeted Nanoparticles
  Multifunctional nanoparticles, formed via polymerization, offer a new approach to delivering anticancer drugs with a high degree of specificity.
  

• Algorithm Enhances Ability To Detect Cancer Genes
  Mapping Tumor Suppressor Genes using Multipoint Statistics from Copy-Number Variation Data
  
• Stomach Receptor For H. Pylori Discovered
  Decay-accelerating Factor (DAF) acts as a Receptor for Helicobacter pylori and a Mediator of Gastric Inflammation
  
• Feinstein Researchers Identify Intelligence Gene
  Genetic variation in DTNBP1 influences general cognitive ability
  
• RNA interference (RNAi) is coming of age as a therapeutic modality
  With four clinical stage projects and 14 projects approaching IND status within the next year, RNAi is evolving as a new therapeutic modality.
  

• The bald truth in the genes
  Combing of the genes to help prevent cancer, researchers suggest a particular gene may have some fringe benefit.
  

• New Medication To Help Treat Alcohol Dependence
  The medicine, Naltrexone was shown to be just as effective specialized counseling for alcohol dependence when delivered with medical management.
  
• Anthrax Toxin Inhibitor Designed
  Technique May Also be Applicable to Other Disease Toxins
  
• Genetic Link Between Eczema, Psoriasis, Asthma, and Hay Fever
  Just the right balance of connexin 26 is required to keep skin and mucosal barriers from causing immune reactions.
  

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