home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Enzyme Regulator of Attention Provides Insights into ADHD

  April, 23 2009 8:12
your information resource in human molecular genetics

Scientists have discovered a key enzyme in the brain of rats that helps regulate attention and hyperactivity. The research could help in the development of new medications for Attention Deficit/Hyperactivity Disorder (ADHD).

Online in the journal Neuropsychopharmacology, Bill Carlezon and colleagues selectively disrupted the function of protein kinase-A (PKA) in the prefrontal cortex - a part of the brain associated with decision making. The rats became hyperactive and were unable to pay attention to hints about how to obtain food. Genetic disruption of a protein which PKA regulates also produced inattention, identifying a pathway within the nerve cells of the prefrontal cortex that might be sluggish in individuals with attention disorders. Additional studies suggested that disruption of PKA did not change the rats' desire for the food, only their ability to pay attention to information needed to obtain it.

Many children struggle with ADHD, a disabling condition that interferes with their ability to focus attention and perform well in school. 'Our hope is that this will lead to the development of medications that have a more narrow range of actions, without producing the side-effects that detract from the actions of current drug treatments,' said Bill Carlezon, senior author on the report.

Author contact:

Bill Carlezon (Harvard Medical School, Belmont, MA)
E-mail: bcarlezon@mclean.harvard.edu

Abstract available online.

(C) Neuropsychopharmacology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.