home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

New Approach to Cancer Treatment

 
  April, 23 2009 7:42
your information resource in human molecular genetics
 
     

A new drug that shows robust anti-tumour activity in a preclinical mouse model of cancer, is reported in Nature. The molecule, called MLN4924, is currently being evaluated in several phase I clinical trials.

MLN4924 suppresses the growth of human cancer cells that have been transplanted into mice, Teresa Soucy and colleagues report. It works by blocking an upstream step in a major intracellular pathway that regulates protein degradation. Another inhibitor of the pathway that targets the proteasome, bortezomib (Velcade), is already in clinical use for certain types of blood cancer. Bortezomib works by inhibiting a downstream step in the same pathway, so MLN4924 may have different clinical potential.

The new molecule also works by a different mechanism. It deregulates the part of the cell cycle, called S-phase, where DNA synthesis occurs. This results in DNA damage and the induction of programmed cell death or cancer cell 'suicide'.

CONTACT

Teresa Soucy (Millennium Pharmaceuticals, Cambridge, MA, USA)
E-mail: teresa.soucy@mpi.com

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.