Genes behind fatal lung disease identified Scientists at Maryland's Johns Hopkins University say they have identified the genetic mutations that trigger a hereditary form of fatal lung disease.
Cancer-Specific Imaging in Mice New imaging compound in mice that selectively binds to certain cancer cells and glows, or fluoresces, only when processed by these cells.
A Potential Therapeutic Agent For Retinoblastoma A natural agent derived from the bark of the South-American lapacho tree inhibits growth and induces cell death in human retinoblastoma cell lines.
Novel Pathway For Antibiotics-induced Cell Death Scientists have identified unforeseen mechanisms by which quinolones - a family of broad-spectrum antibiotics among the most widely prescribed - induce bacterial cell death.
Laying Sleeping Sickness To Rest The parasite that leads to sleeping sickness can be lulled to sleep itself using a newly discovered pathway.
Jumonji Family Removing The Mark Two papers identify a sought-after regulator of 'marks' on the chromatin that are associated with whether the genes are switched on or off.
Bacteria-mediated Immune System Paralysis How the pathogen Staphylococcus aureus, a leading cause of hospital-related infections, disables the immune system is described.
Understanding Cancer Spread A signalling pathway that enhances the formation of metastases in a mouse model of prostate cancer has been identified.
Cancer Genomes Probed Biologists have sequenced over 500 protein kinase genes found in 210 diverse human cancers and identified over 1,000 different mutations.
Sotos Syndrome The NSD1 mutational spectrum has been defined, the phenotype of Sotos syndrome clarified and diagnostic and management guidelines developed.
Parents Who Live Long Pass On Lower Risk of Cardiovascular Disease People whose parents live longer are more likely to avoid developing high blood pressure, high cholesterol, and other risk factors for cardiovascular disease in middle age than their peers whose parents died younger.
Imatinib Could Cause Tumour Regression The first targeted anticancer drug to specifically inhibit an enzyme that causes cancer cell growth might also promote tumour regression.
Potential Therapeutic Target In Down Syndrome Blocking the actions of an inhibitory neurotransmitter can improve performance in several memory tasks in a mouse model of Down syndrome.
Proteins A La Carte A method to incorporate non-naturally occurring amino acids into proteins in mammalian cells is described.
Genomic Marker For Lung Cancer Gene expression patterns in lung airway cells from smokers may aid the early detection of lung cancer.
A Natural Barrier To HIV Transmission A protein in one of the first immune cells encountered by HIV as it enters the body acts as a natural barrier to transmission of the virus.
New Immune Cell Exit Strategy Immune cells recruited to sites of infection can use more than one type of molecule to exit the bloodstream.
Tumour Suppressor Linked To Heart Failure? Inhibition of angiogenesis by the tumour suppressor protein p53 may have a critical role in the progression of cardiac hypertrophy to cardiac failure.