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To: list@hum-molgen.de
Subject: HUM-MOLGEN News Alert - December 14, 2005
From: FS Zollmann <zollmann@hum-molgen.de>
Date: Wed, 14 Dec 2005 13:58:49 +0100

__________________________________________________________________________

   CHI's Molecular Medicine Tri-Conference 2006

   Genome Drug Discovery, Business Strategies, Target-Driven Chemistry and
   Strategic Biocomputing are the four tracks of CHIís Molecular Medicine
   Marketplace

   February 21-24, 2006 - San Francisco, California

   http://hum-molgen.org/promotion-tri
__________________________________________________________________________


INTERNATIONAL COMMUNICATION FORUM IN HUMAN MOLECULAR GENETICS
HUM-MOLGEN News Alert - December 14, 2005 - http://hum-molgen.org


SEASON'S GREETINGS AND HAPPY NEW YEAR

from Trevor M. D'Souza, Simon Chandler, Tressie Dalaya, Kai Garlipp,
Anthony W.I. Lo, Keith Markey,  Jonathan Mill, Rashmi V. Nemade,
Deepti Sharma and Frank S. Zollmann


Genetic News
by T.M. D'Souza, S. Chandler, T. Dalaya, K. Markey, J. Mill, La Merie S.L,
R. Nemade, D. Sharma, F.S. Zollmann
http://hum-molgen.org/NewsGen

- Wealth, Not Chemicals, Increase Breast Cancer Risk
    Women who live in certain regions of the United States have a
    significant increase in breast cancer risk, compared with the rest of
    the US, but this is an effect of affluence rather than pollution.
    http://hum-molgen.org/NewsGen/12-2005/msg22.html

- A Cracked Mirror In Autistic Children
    Autistic children have less activation in a brain area containing
    neurons that are involved in understanding others' state of mind.
    http://hum-molgen.org/NewsGen/12-2005/msg21.html

- Boosting Gene Expression On The X
    Study finds that genes present on the X chromosome are expressed at
    approximately the same level as those found on non-sex chromosomes.
    http://hum-molgen.org/NewsGen/12-2005/msg20.html

- Potholes Common In The Human Genome
    Three new studies highlight the dramatic and very common ways in
    which the genomes of individual people can differ from one another.
    http://hum-molgen.org/NewsGen/12-2005/msg19.html

- Tumours Prepare Sites Of Metastasis Formation
    Study finds that tumours help prepare remote sites in the body for
    the formation of metastases.
    http://hum-molgen.org/NewsGen/12-2005/msg18.html

- Viruses Need To Make Mistakes To Better Infect Hosts
    Certain (RNA) viruses that copy their genome too accurately are less
    infectious than normal viruses.
    http://hum-molgen.org/NewsGen/12-2005/msg17.html

- Epistasis Unravelled In Bardet-Biedl Syndrome
    Scientists have succeeded in demonstrating and dissecting epistasis
    in Bardet-Biedl syndrome (BBS), an illness often characterized by
    obesity and learning deficits.
    http://hum-molgen.org/NewsGen/12-2005/msg16.html

- How HIV Keeps Hiding
    Researchers have found a way to explain how the human
    immunodeficiency virus (HIV) can be kept dormant and hidden in immune
    cells.
    http://hum-molgen.org/NewsGen/12-2005/msg15.html

- Showing Strong Association with Late-Onset Alzheimer Disease
    Variants in the RPS3A homologue are associated with late-onset
    Alzheimer disease (LOAD) and implicate this gene, adjacent genes, or
    other functional variants (e.g., noncoding RNAs) in the pathogenesis
    of this disorder.
    http://hum-molgen.org/NewsGen/12-2005/msg14.html

- Strong Genetic Evidence of DCDC2 as a Susceptibility Gene for Dyslexia
    Study showed that DCDC2, which contains a doublecortin homology
    domain that is possibly involved in cortical neuron migration, is
    expressed in the fetal and adult CNS.
    http://hum-molgen.org/NewsGen/12-2005/msg13.html

- A Testing Framework for Identifying Susceptibility Genes in the
   Presence of Epistasis
    An efficient testing strategy called the "focused interaction testing
    framework" (FITF) was developed to identify susceptibility genes
    involved in epistatic interactions for case-control studies of
    candidate genes.
    http://hum-molgen.org/NewsGen/12-2005/msg12.html

- Determinants of Exon 7 Splicing in the Spinal Muscular Atrophy Genes,
   SMN1 and SMN2
    The authors report the extensive testing of the enhancer-loss and
    silencer-gain models by mutagenesis, RNA interference,
    overexpression, RNA splicing, and RNA-protein interaction
    experiments.
    http://hum-molgen.org/NewsGen/12-2005/msg11.html

- A Germline Mutation in BLOC1S3/Reduced Pigmentation Causes a Novel
   Variant of Hermansky-Pudlak Syndrome (HPS8)
    These findings define a novel form of human HPS (HPS8) and extend
    genotype-phenotype correlations in HPS.
    http://hum-molgen.org/NewsGen/12-2005/msg10.html

- Two telltales: a tale of a tail
    Continuing his work on Histone H3 epigenetic modifications, Allis and
    coworkers show the regulation of pericentromeric HP1 binding by two
    simultaneous modifications of adjacent residues in Histone H3
    http://hum-molgen.org/NewsGen/12-2005/msg08.html

- Understanding how we sense taste
    Two key receptors involved in taste show how taste is communicated to
    the brain.
    http://hum-molgen.org/NewsGen/12-2005/msg07.html

- Virtual Colonoscopy: The Future of Cancer Detection
    Computer-Aided Polyp Detection Software in Combination with Virtual
    Colonoscopy is as Effective as Traditional Optical Colonoscopy
    http://hum-molgen.org/NewsGen/12-2005/msg06.html

- Progressive Aphasia Syndrome linked to Prion Gene
    First evidence that there may be a specific gene involved in
    progressive aphasia syndrome.
    http://hum-molgen.org/NewsGen/12-2005/msg05.html

- Gene for Fear Discovered: Implications for Anxiety Disorders
    When the gene for stathmin is knocked out, mice showed less anxiety
    and are prone to more exploration.
    http://hum-molgen.org/NewsGen/12-2005/msg04.html

- Defective gene associated with altered brain development and reading
   disability
    A study into the genetic basis of reading disability has identified a
    deletion in the DCDC2 gene, located on chromosome 6p22, that
    predisposes individuals to the disorder.
    http://hum-molgen.org/NewsGen/12-2005/msg03.html

- Choroidal Neovascularisation Ė Do you give an Eph?
    Apparently so; in a recent publication, scientists show that that
    introduction of soluble EphB4 efficiently inhibits VEGF-induced
    migration, tube formation and neovascularisation.
    http://hum-molgen.org/NewsGen/12-2005/msg02.html

- Cardiovascular safety determines the direction of PPAR agonist R&D
    The two peroxisome proliferator-activated receptor (PPAR) gamma
    agonists pioglitazone and rosiglitazone approved for treatment of
    type 2 diabetes achieved combined 2004 global sales of US$ 3.96 bln
    http://hum-molgen.org/NewsGen/12-2005/msg01.html

- Contact Genetic News editors
   WWW: http://hum-molgen.org/editors.html
   E-mail: news@hum-molgen.org


DIAGnostics - Clinical Research (professional requests)
http://hum-molgen.org/clinical-research/

- Post diagnostic request / call for collaboration
   http://hum-molgen.org/diagnostic-posting or
   contact admin@hum-molgen.org


Biotechnical requests and sources
http://hum-molgen.org/biotechnology

- Short Tandem Repeat Polymorphisms are here to stay!
    http://hum-molgen.org/bb/Forum1/HTML/000159.html


Biomedical Positions
http://hum-molgen.org/positions/

- Biotechnology: Post-doctoral Fellow
    Alagappa University, Karaikudi, 630 003, India
    http://hum-molgen.org/positions/postdocs/2607.html

- Cell and Molecular Biology / Anatomy: POST-DOCTORAL FELLOW
    ST GEORGE HOSPITAL, KOGARAH 2217 AUSTRALIA
    http://hum-molgen.org/positions/postdocs/2608.html

- Genetics: Junior and senior scientists
    Progenika biopharma, SA, Derio, Vizcaya. E-48160, Spain
    http://hum-molgen.org/positions/non_academic_positions/1683.html

- Call for Assistant News Editors
   To further strengthen our news section we are currently looking for:
   Assistant Editors for the HUM-MOLGEN News section
   http://hum-molgen.org/NewsGen/04-2003/msg01.html

- Write a position announcement
   http://hum-molgen.org/flyer/positions.pdf
   1) Set up account: http://hum-molgen.de/cgi-bin/positions.pl?register
   2) Post position(s): http://hum-molgen.de/cgi-bin/positions.pl?login


Literature
http://hum-molgen.org/literature/

- Lectures from HGM2005
    Powerpoint & PDF Presentations
    http://hum-molgen.org/literature/12-2005/msg01.html


Events in bioscience and medicine
http://hum-molgen.org/meetings/

- Post event (free)
   http://hum-molgen.de/cgi-bin/meetings.pl?login


Registry of Biomedical Companies (1249 active entries)
http://hum-molgen.org/companies/


Mailing List Administration (Join or leave the list)
http://hum-molgen.org/subscribe-na/


Feedback
contact admin@hum-molgen.org


Advertise at HUM-MOLGEN
http://hum-molgen.org/flyer/advertise.pdf
contact FS Zollmann (dialogue@hum-molgen.org)

__________________________________________________________________________

   CHI's Molecular Medicine Tri-Conference 2006

   Genome Drug Discovery, Business Strategies, Target-Driven Chemistry and
   Strategic Biocomputing are the four tracks of CHIís Molecular Medicine
   Marketplace

   February 21-24, 2006 - San Francisco, California

   http://hum-molgen.org/promotion-tri
__________________________________________________________________________ 





   
 
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