HUM-MOLGEN archive: HUM-MOLGEN News Alert

__________________________________________________________________________ CHI's Molecular Medicine Tri-Conference 2006 Genome Drug Discovery, Business Strategies, Target-Driven Chemistry and Strategic Biocomputing are the four tracks of CHI’s Molecular Medicine Marketplace February 21-24, 2006 - San Francisco, California http://hum-molgen.org/promotion-tri __________________________________________________________________________ INTERNATIONAL COMMUNICATION FORUM IN HUMAN MOLECULAR GENETICS HUM-MOLGEN News Alert - December 14, 2005 - http://hum-molgen.org SEASON'S GREETINGS AND HAPPY NEW YEAR from Trevor M. D'Souza, Simon Chandler, Tressie Dalaya, Kai Garlipp, Anthony W.I. Lo, Keith Markey, Jonathan Mill, Rashmi V. Nemade, Deepti Sharma and Frank S. Zollmann Genetic News by T.M. D'Souza, S. Chandler, T. Dalaya, K. Markey, J. Mill, La Merie S.L, R. Nemade, D. Sharma, F.S. Zollmann http://hum-molgen.org/NewsGen - Wealth, Not Chemicals, Increase Breast Cancer Risk Women who live in certain regions of the United States have a significant increase in breast cancer risk, compared with the rest of the US, but this is an effect of affluence rather than pollution. http://hum-molgen.org/NewsGen/12-2005/msg22.html - A Cracked Mirror In Autistic Children Autistic children have less activation in a brain area containing neurons that are involved in understanding others' state of mind. http://hum-molgen.org/NewsGen/12-2005/msg21.html - Boosting Gene Expression On The X Study finds that genes present on the X chromosome are expressed at approximately the same level as those found on non-sex chromosomes. http://hum-molgen.org/NewsGen/12-2005/msg20.html - Potholes Common In The Human Genome Three new studies highlight the dramatic and very common ways in which the genomes of individual people can differ from one another. http://hum-molgen.org/NewsGen/12-2005/msg19.html - Tumours Prepare Sites Of Metastasis Formation Study finds that tumours help prepare remote sites in the body for the formation of metastases. http://hum-molgen.org/NewsGen/12-2005/msg18.html - Viruses Need To Make Mistakes To Better Infect Hosts Certain (RNA) viruses that copy their genome too accurately are less infectious than normal viruses. http://hum-molgen.org/NewsGen/12-2005/msg17.html - Epistasis Unravelled In Bardet-Biedl Syndrome Scientists have succeeded in demonstrating and dissecting epistasis in Bardet-Biedl syndrome (BBS), an illness often characterized by obesity and learning deficits. http://hum-molgen.org/NewsGen/12-2005/msg16.html - How HIV Keeps Hiding Researchers have found a way to explain how the human immunodeficiency virus (HIV) can be kept dormant and hidden in immune cells. http://hum-molgen.org/NewsGen/12-2005/msg15.html - Showing Strong Association with Late-Onset Alzheimer Disease Variants in the RPS3A homologue are associated with late-onset Alzheimer disease (LOAD) and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder. http://hum-molgen.org/NewsGen/12-2005/msg14.html - Strong Genetic Evidence of DCDC2 as a Susceptibility Gene for Dyslexia Study showed that DCDC2, which contains a doublecortin homology domain that is possibly involved in cortical neuron migration, is expressed in the fetal and adult CNS. http://hum-molgen.org/NewsGen/12-2005/msg13.html - A Testing Framework for Identifying Susceptibility Genes in the Presence of Epistasis An efficient testing strategy called the "focused interaction testing framework" (FITF) was developed to identify susceptibility genes involved in epistatic interactions for case-control studies of candidate genes. http://hum-molgen.org/NewsGen/12-2005/msg12.html - Determinants of Exon 7 Splicing in the Spinal Muscular Atrophy Genes, SMN1 and SMN2 The authors report the extensive testing of the enhancer-loss and silencer-gain models by mutagenesis, RNA interference, overexpression, RNA splicing, and RNA-protein interaction experiments. http://hum-molgen.org/NewsGen/12-2005/msg11.html - A Germline Mutation in BLOC1S3/Reduced Pigmentation Causes a Novel Variant of Hermansky-Pudlak Syndrome (HPS8) These findings define a novel form of human HPS (HPS8) and extend genotype-phenotype correlations in HPS. http://hum-molgen.org/NewsGen/12-2005/msg10.html - Two telltales: a tale of a tail Continuing his work on Histone H3 epigenetic modifications, Allis and coworkers show the regulation of pericentromeric HP1 binding by two simultaneous modifications of adjacent residues in Histone H3 http://hum-molgen.org/NewsGen/12-2005/msg08.html - Understanding how we sense taste Two key receptors involved in taste show how taste is communicated to the brain. http://hum-molgen.org/NewsGen/12-2005/msg07.html - Virtual Colonoscopy: The Future of Cancer Detection Computer-Aided Polyp Detection Software in Combination with Virtual Colonoscopy is as Effective as Traditional Optical Colonoscopy http://hum-molgen.org/NewsGen/12-2005/msg06.html - Progressive Aphasia Syndrome linked to Prion Gene First evidence that there may be a specific gene involved in progressive aphasia syndrome. http://hum-molgen.org/NewsGen/12-2005/msg05.html - Gene for Fear Discovered: Implications for Anxiety Disorders When the gene for stathmin is knocked out, mice showed less anxiety and are prone to more exploration. http://hum-molgen.org/NewsGen/12-2005/msg04.html - Defective gene associated with altered brain development and reading disability A study into the genetic basis of reading disability has identified a deletion in the DCDC2 gene, located on chromosome 6p22, that predisposes individuals to the disorder. http://hum-molgen.org/NewsGen/12-2005/msg03.html - Choroidal Neovascularisation – Do you give an Eph? Apparently so; in a recent publication, scientists show that that introduction of soluble EphB4 efficiently inhibits VEGF-induced migration, tube formation and neovascularisation. http://hum-molgen.org/NewsGen/12-2005/msg02.html - Cardiovascular safety determines the direction of PPAR agonist R&D The two peroxisome proliferator-activated receptor (PPAR) gamma agonists pioglitazone and rosiglitazone approved for treatment of type 2 diabetes achieved combined 2004 global sales of US$ 3.96 bln http://hum-molgen.org/NewsGen/12-2005/msg01.html - Contact Genetic News editors WWW: http://hum-molgen.org/editors.html E-mail: news@hum-molgen.org DIAGnostics - Clinical Research (professional requests) http://hum-molgen.org/clinical-research/ - Post diagnostic request / call for collaboration http://hum-molgen.org/diagnostic-posting or contact admin@hum-molgen.org Biotechnical requests and sources http://hum-molgen.org/biotechnology - Short Tandem Repeat Polymorphisms are here to stay! http://hum-molgen.org/bb/Forum1/HTML/000159.html Biomedical Positions http://hum-molgen.org/positions/ - Biotechnology: Post-doctoral Fellow Alagappa University, Karaikudi, 630 003, India http://hum-molgen.org/positions/postdocs/2607.html - Cell and Molecular Biology / Anatomy: POST-DOCTORAL FELLOW ST GEORGE HOSPITAL, KOGARAH 2217 AUSTRALIA http://hum-molgen.org/positions/postdocs/2608.html - Genetics: Junior and senior scientists Progenika biopharma, SA, Derio, Vizcaya. E-48160, Spain http://hum-molgen.org/positions/non_academic_positions/1683.html - Call for Assistant News Editors To further strengthen our news section we are currently looking for: Assistant Editors for the HUM-MOLGEN News section http://hum-molgen.org/NewsGen/04-2003/msg01.html - Write a position announcement http://hum-molgen.org/flyer/positions.pdf 1) Set up account: http://hum-molgen.de/cgi-bin/positions.pl?register 2) Post position(s): http://hum-molgen.de/cgi-bin/positions.pl?login Literature http://hum-molgen.org/literature/ - Lectures from HGM2005 Powerpoint & PDF Presentations http://hum-molgen.org/literature/12-2005/msg01.html Events in bioscience and medicine http://hum-molgen.org/meetings/ - Post event (free) http://hum-molgen.de/cgi-bin/meetings.pl?login Registry of Biomedical Companies (1249 active entries) http://hum-molgen.org/companies/ Mailing List Administration (Join or leave the list) http://hum-molgen.org/subscribe-na/ Feedback contact admin@hum-molgen.org Advertise at HUM-MOLGEN http://hum-molgen.org/flyer/advertise.pdf contact FS Zollmann (dialogue@hum-molgen.org) __________________________________________________________________________ CHI's Molecular Medicine Tri-Conference 2006 Genome Drug Discovery, Business Strategies, Target-Driven Chemistry and Strategic Biocomputing are the four tracks of CHI’s Molecular Medicine Marketplace February 21-24, 2006 - San Francisco, California http://hum-molgen.org/promotion-tri __________________________________________________________________________