HUM-MOLGEN archive: NEWS: in Bioscience and Medicine

************************************************************** HUM-MOLGEN News in Bioscience and Medicine ************************************************************** News in Bioscience and Medicine: http://www.informatik.uni-rostock.de/HUM-MOLGEN/NewsGen/ HUM-MOLGEN WWW: http://www.informatik.uni-rostock.de/HUM-MOLGEN/ -------------------------------------------------------------------- Summary of recent postings: -------------------------------------------------------------------- 1 | Human 2D PAGE Databases for Proteome Analysis 2 | 9/18/96: Infectious Diseases Kill 12 Million Children Each Year 3 | The Mouse Atlas Project 4 | Hematology Physicians Discussion List (HEM-Dr) 5 | HotMolecBase 6 | NCHGR-DOE Guidance on Human Subjects Issues in Large-Scale DNA Sequencing 7 | Biochemistry Online 8 | NIGMS Human Genetic Mutant Cell Repository catalog 9 | GENETIC VARIANTS OF THE HUMAN OBESITY (OB) GENE ... 10 | How to announce new Internet resources, press releases etc. -------------------------------------------------------------------- 1 | Human 2D PAGE Databases for Proteome Analysis | WWW: http://biobase.dk/cgi-bin/celis | E-mail: jec@biokemi.aau.dk The following human databases are available: keratinocytes, transitional cell carcinomas, MRC-5 fibroblats and urine. You can display protein names and information on specific protein spots by clicking on the image of the gel representing the 2-D gel map in which you are interested. Also, you can search by protein name or organelle or cellular component. -------------------------------------------------------------------- 2 | 9/18/96: Infectious Diseases Kill 12 Million Children Each Year | WWW: http://WWW.IH.JHU.EDU/ | E-mail: RBLACK@PHNET.SPH.JHU.EDU Full text available at http://www.informatik.uni-rostock.de/HUM-MOLGEN/NewsGen/ -------------------------------------------------------------------- 3 | The Mouse Atlas Project | WWW: http://glengoyne.hgu.mrc.ac.uk/ The UK MRC Human Genetics Unit in Edinburgh is currently developing a digital atlas of mouse development and database to be a resource for spatially mapped data such as in situ gene expression and cell lineage. The project is in collaboration with the Department of Anatomy, University of Edinburgh, the Jackson Laboratory, USA and a European Science Foundation Network. -------------------------------------------------------------------- 4 | Hematology Physicians Discussion List (HEM-Dr) | E-mail: romeo-mandanas@uokhsc.edu HEM-Dr (Hematology Physicians Discussion List) is a private mailing list designed mainly for physicians and the discussion of issues in hematology or blood, bone marrow or lymph gland disorders. Medical doctors, PhDs, and scientists working in the field of hematology or hematopathology as well as referring physicians are invited to participate in this discussion list. Patients and their loved ones who are seeking support group or hematology-related information are referred to either of two separate lists called HEM-ONC or MPD-NET. Hematology deals with the study of both benign disorders of the blood, bone marrow and lymph glands as well as malignant diseases such as leukemias and lymphomas. HEM-Dr allows a private network of parties involved in hematology to conduct rapid exchange of informal discussions on various issues to ultimately foster better patient care and outcome. To join the list or contact the listowners, write to: HEM-Dr-request@sjuvm.stjohns.edu Romeo A. Mandanas M.D. HEM-Dr Listowner romeo-mandanas@uokhsc.edu -------------------------------------------------------------------- 5 | HotMolecBase | WWW: http://bioinformatics.weizmann.ac.il/hotmolecbase/ | E-mail: lvrebhan@bioinformatics.weizmann.ac.il Reply to [the Author] Looking for molecules playing a central role in the pathogenesis of the disease you are interested in? Or are you searching for useful monoclonal antibodies directed against a certain antigen; for the cellular function(s), or the expression pattern of a certain protein? Then HotMolecBase, the database about medically interesting molecules, may be an interesting site to visit. To see what it's all about, have a look into the typical entry, or try the simple-to-use search engine. If you cannot find the information you're searching for, contact the author, and send him some words describing your problems, so that this ever evolving web service may adjust to your needs. -------------------------------------------------------------------- 6 | NCHGR-DOE Guidance on Human Subjects Issues in Large-Scale DNA Sequencing | WWW: http://www.ornl.gov/TechResources/Human_Genome/archive/nchgrdoe.html The Human Genome Project (HGP) is now entering into large-scale DNA sequencing. To meet its complete sequencing goal, it will be necessary to recruit volunteers willing to contribute their DNA for this purpose. The guidance is intended to address ethical issues that must be considered in designing strategies for recruitment and protection of DNA donors for large-scale sequencing. -------------------------------------------------------------------- 7 | Biochemistry Online | WWW: http://www.arach-net.com/~jlyon/biochem/index.html | E-mail: vtga@uhura.cc.rochester.edu Announcing Biochemistry Online, an internet based journal. Can be accessed at http://www.arach-net.com/~jlyon/biochem/index.html The third issue can be viewed at the following site : http://www.arach-net.com/~jlyon/biochem/issue3/index.html Also, calling for papers for publication in the future issues of the journal. Querries can be addressed to either Justin Lyon at mailto:jlyon@trib.net or to Vineet Gupta at vtga@uhura.cc.rochester.edu Thanx, Vineet Gupta Editor Biochemistry Online -------------------------------------------------------------------- 8 | NIGMS Human Genetic Mutant Cell Repository catalog | WWW Home Page | E-mail: jbeck@umdnj.edu A World Wide Web version of the NIGMS Human Genetic Mutant Cell Repository catalog is now available (http://arginine.umdnj.edu/coriell/nigms.htm). The Repository has human cell cultures available in the following categories: inherited metabolic disorders, biochemically mutant cell cultures with characterized mutations, well-characterized chromosomally aberrant cell cultures, CEPH Reference Families, a human diversity collection, and human/rodent somatic cell hybrid mapping panels. Menus are provided to allow users to search for cell cultures or DNA samples in a variety of ways, including Repository number, MIM number, disease description, as well as chromosome abnormality and number. Chromosome ideograms are provided for human/rodent somatic cell hybrids. -------------------------------------------------------------------- 9 | GENETIC VARIANTS OF THE HUMAN OBESITY (OB) GENE ... | E-mail: LICINIO@NIH.GOV PRESS RELEASE GENETIC VARIANTS OF THE HUMAN OBESITY (OB) GENE: ASSOCIATION WITH BODY MASS INDEX IN YOUNG WOMEN, PSYCHIATRIC SYMPTOMS, AND INTERACTION WITH THE DOPAMINE D2 RECEPTOR (DRD2) GENE. DE Comings, R Gade, J MacMurray, D Muhleman, P Johnson, R Verde, WR Peters. City of Hope National Medical Center, Duarte, California, USA and Loma Linda University, Loma Linda, California, USA Molecular Psychiatry 1996; vol. 1, issue 4 (September 1996). In a study reported in the current issue of the journal Molecular Psychiatry, researchers at City of Hope National Medical Center, Duarte, California, USA and Loma Linda University, Loma Linda, California, USA examined a complex, genetically variable region (polymorphism) close to the human obesity (OB) gene and found that certain genetic variants next to the human OB gene are associated with obesity in young women, but not young men. They also found that the genetic variants at the OB gene were also associated in these women with depression and anxiety, two of the behaviors most often associated with obesity. The results suggest the depression was a direct result of the OB gene variants and not just secondary to the obesity. The cloning and sequencing of the mouse and the human obesity (OB) genes have been greeted with enormous excitement. When mice have a defective OB gene on both chromosomes, they are very obese and treatment with leptin, the product of the OB gene, causes rapid weight loss. This led to the hope that obese humans also had a defective OB gene, and treatment with leptin would also cause weight loss. However, many subsequent studies have shown that obese humans have too much leptin, not too little, and no mutations of the OB gene itself were found. Thus, the OB gene - leptin story is far more complex than originally thought. In 1993 DE Comings and colleagues found that variants of the dopamine D2 receptor gene (DRD2), originally reported by K Blum and EP Noble as being associated with severe alcoholism, were also associated with obesity. Blum and Noble confirmed this association, and both groups found an association between the DRD2 gene and drug addiction. All three of these substances (alcohol, drugs and food), stimulate the reward pathways of the brain. Now Comings and coworkers found that the OB and DRD2 genes were additive in their effect on obesity in young women. Both genes combined accounted for 22% of the obesity in young women. These results are consistent with obesity being the result of many different genes (polygenic), with a greater involvement of genetic factors in women and younger subjects, and suggest that variants of the OB gene are causally involved not only with human obesity but with its associated behavioral disorders. An independent commentary by Dr. Gerald J. LaHoste (University of California at Irvine, USA; FAX: + 1 714 824-2447; phone: +1 714 824-4722; e-mail: glahoste@parker.bio.uci.edu) also appears in the current issue of Molecular Psychiatry. EMBARGOED UNTIL SEPTEMBER 15, 1996 This article will be published in the September issue of Molecular Psychiatry, a peer-reviewed journal published by Stockton Press/Macmillan Press. Editor: Julio Licinio, MD - editorial assistant: Rachel Lisman NIH, Bldg. 10/2D46, 10 Center Drive, Bethesda, MD 20892-1284, USA phone: (301) 496-6885; FAX: +1 (301) 402-1561; e-mail: licinio@nih.gov Publisher: Marija Vukovojac, phone and FAX: +44 1483 892119 e-mail: 100743.2265@CompuServe.COM For information on the scientific aspects of the article please contact the author: Dr. David E. Comings, Department of Medical Genetics, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010-0269, USA phone: +1 (818) 359-8111; FAX: +1 (818) 301-8980 -------------------------------------------------------------------- 10 | How to announce new Internet resources, press releases etc. You can announce (free) new Internet resources, press releases etc. at http://www.informatik.uni-rostock.de/cgi-bin/HMB/NewsGen/vw3news?postF For other announcements please take a look at http://www.informatik.uni-rostock.de/HUM-MOLGEN/hum/submit.html -------------------------------------------------------------------- Neither the owner nor the editors of HUM-MOLGEN can be held liable in any way for the contents, or part of the contents, or even phrases of messages appearing on HUM-MOLGEN or it's TOPICs. 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