HUM-MOLGEN archive: DIAG: 2 messages + editor note (please LOOK at it)

************************************************************** HUM-MOLGEN DIAGnostics/Clinical Research ************************************************************** This DIAG message contains 3 submessage(s): 1) Familial Neuroblastoma Linkage Project 2) Familial papillary thyroid carcinoma 3) Message from the Editor Carlo Gambacorti MD, Editor, Human Molecular Genetics network Diagnostics/Clinical Research Section ************************************************************** ************************************************************** We are interested in the molecular genetics of familial neuroblastoma and have an IRB approved protocol for specimen procurement and linkage analysis. We would appreciate being notified of any patients/families that meet any of the following criteria and whom might be interested in providing a blood sample (archival tumor specimens useful also): 1. Proband with one or more first degree relative with neuroblastoma, ganglioneuroblastoma or ganglioneuroma. 2. Proband affected with and/or with one or more first degree relative with Hirschsprung disease or hypoventilation syndrome. 3. Neuroblastoma patients with any other co-morbid condition (congenital malformations, mental retardation, etc.). We will be happy to provide additional information. Furthermore, we will send copies of consent and specimen procurement forms at your request. Thank you. John M. Maris, MD The Children's Hospital of Philadelphia fax: 215-590-3770 voice: 215 590-5242 email: maris@email.chop.edu ************************************************************** Dear Colleagues, our group at the International Agency for Research on Cancer (IARC) at Lyon, France is setting up a project for the identification of predisposing gene(s) for familiar papillary thyroid carcinoma (PTC) by linkage analyses. For this purpose we are organizing an international consortium. Are you currently following families with recurrence of PTC or do you know of any colleague who might have seen such families? For this project we are interested in blood samples or DNA from at least two affected individuals in the same family. Upon your answer we will send you the protocol of this study, including a clinical questionnaire and the information for blood collection and shipment of this and/or other biological material. Thank you very much in advance for your cooperation. For further information please contact: Dr. G. Romeo International Agency for Research on Cancer 150, Cours Albert-Thomas F-69372 LYON Cedex 08 France Fax: +33 72738575 Tel: +33 72738512 E-mail: romeo@iarc.fr ************************************************************** From march 16 to may 1, 1996, this section will be managed by Bob Resta, HMGN new Associate Editor. We are interested in getting feedbacks from previous postings; therefore we invite all persons who posted messages inside this section, to e- mail to us the following information: 1. one or more key-words appearing in their message; 2. the number of replies received; 3. whether they consider this number as adequate or not. 4. whether they would like to have the message displayed on HMGN web site for 3 months (thus more people could look at them). This information is important (especially to question #4) to continue to improve our service. Thanks. Carlo Gambacorti MD **************************************************************