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Budisa. 2005. Engineering the Genetic Code. 1st ed.

 
  November, 16 2005 6:12
new and historical books in bioscience and medicine
 
     
Budisa, Nediljko
1. Edition - October 2005
119.- Euro / 188.- SFR
2005. XVI, 296 Pages, Hardcover
- Monograph -
ISBN 3-527-31243-9 - Wiley-VCH, Weinheim

=> Wiley

Detailed description

The ability to introduce non-canonical amino acids in vivo has greatly expanded the repertoire of accessible proteins for basic research and biotechnological application.
Here, the different methods and strategies to incorporate new or modified amino acids are explained in detail, including a lot of practical advice for first-time users of this powerful technique.
Novel applications in protein biochemistry, genomics, biotechnology and biomedicine made possible by the expansion of the genetic code are discussed and numerous examples are given.
Essential reading for all molecular life scientists who want to stay ahead in their research.

-> Sample Chapter

From the contents

INTRODUCTION

Classical Approaches for Protein Modification
Protein Total Synthesis
Basic Definitions and Taxonomy

HISTORY OF AN EXPANDED AMINO ACID REPERTOIRE

Cell-free Synthesis of Proteins
Noncanonical Amino Acids as Tools for Studying Metabolism
Genetic Code Engineering

BASIC FEATURES OF THE CELLULAR TRANSLATION APPARATUS

Ribosome-mediated Protein Synthesis
tRNAs and tRNA Synthetases
Translational Proofreading
Ribosomal Decoding, Codon Bias and Translational Fidelity
Context-dependent Recoding
Post-translational Modifications

GENETIC CODE ORGANISATION AND PROTEIN STRUCTURE

The Universal Genetic Code
Natural Variations in Codon Assignment
Codon Reassignment and Codon Ambiguity

REPROGRAMMING THE CELLULAR TRANSLATION MACHINERY

Enzyme Specificity and Code Interpretation
Reassigning Coding and Non-Coding Units
In vitro Chemical and Enzymatic tRNA Aminoacylation
Novel Codon-Anticodon Base Pairs
Stop Codon Takover
Suppression-Based Methods
Future Approaches

IMPLICATIONS AND INSIGHTS

Evolution of the Amino Acid Repertoire
Artificial Genetic Systems
De novo Design of Organisms
Chances and Risks

APPLICATIONS FOR REPROGRAMMED CELLULAR TRANSLATION

Genetically Encoded Protein Surface Diversity
Applications in Structural Biology
Atomic Mutations
Protein Folding, Stability and Design
Tailoring Protein Spectroscopy
Protein-based Sensors
Applications in Biomedicine
Noncanonical Amino Acids with Neurological Activity


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