Klipp et al. 2005. Systems Biology in Practice. 1st ed.

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Short description

Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation.

It provides readers with guidance on how a specific complex biological question may be tackled:

* How to formulate questions that can be answered
* Which experiments to perform
* Where to find information in databases and on the Internet
* What kinds of models are appropriate
* How to use simulation tools
* What can be learned from the comparison of experimental data and modeling results
* How to make testable predictions.

The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.

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From the contents

Introduction

FIRST PART: GENERAL INTRODUCTION
Some Basic Principles
Biology in a Nut Shell
Mathematics in a Nut Shell
Experimental Techniques in a Nut Shell

SECOND PART: STANDARD MODELS AND APPROACHES IN SYSTEMS BIOLOGY
Metabolism
Signal Transduction
Special Biological Processes
Modeling of Gene Expression
Analysis of Gene Expression and Gene Network Reconstruction
Self-Organization and Evolution
Data Integration
What's next?

THIRD PART: COMPUTER-BASED INFORMATION RETRIEVAL AND EXAMINATION
Databases and Tools on the Internet
Modelling Tools

Glossary