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Neurogenetics

Eye tracking dysfunction (ETD) has been discussed as a phenotypic marker of genetic liability to schizophrenia. We present results of 9 German families (79 members) with multiple occurrence of schizophrenia. Family members were investigated with regard to: a) psychiatric disorders based on DSM III-R; b) ETD, defined by velocity criteria and the number of saccades occurring during smooth pursuit of a horizontally moving target (30 o/s); c) 12 markers in a candidate region for schizophrenia on chromosome 6p11-p23. ETD resp. schizophrenia was treated as an autosomal dominant trait with penetrances for heterozygotes = 0.8 resp. 0.2 and homozygotes = 0.9 resp. 0.235, gene frequency = 0.01 and probability of affection for non-gene carriers = 0.026 resp. 0.0063. The maximum LOD-score we obtained for ETD by two point analysis is 2.03, = 0.0, at marker D6S426. For disorders of the schizophrenia spectrum the LOD-score is only 1.16, =0.0, at marker D6S274. There is no significant indication of heterogeneity.

Conclusions:
1. In linkage studies in candidate regions for schizophrenia, ETD seems to be a better phenotypic marker than psychopathological symptoms.
2. Suggestion for a candidate region on chromosome 6p11-p23 is given as proposed by several authors (Kendler et al., Virgina; Wang et al., Bethesda; Wildenauer et al., Munich; Moises et al., Kiel), recently.


Headings
Eye tracking dysfunction (ETD)
schizophrenia

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